I only took these supplements for 3 days in a row, at the daily dose of:
Leucine 5.2 grams
Glutamine 5.8 grams
I did not notice much during that short test, except perhaps being in a more relaxed and good humored mood.
Any reason why you stopped?
I plan on doing the same, but with BCAAs and Glutamine. Will report back when I do it.
Hi,
I've read several comments on this thread that seem to indicate confusion, so I'll make a few statements to try to clear up a few things.
Ron did not get mTOR ideas from Fluge and Mella. He says F and M did not do sequencing. Ron started thinking about mTOR when he discovered through sequencing in the Genome Center that TWO me/cfs patients had mutations in that gene. He realized when he saw that that it could be important because mTOR is a major regulator of things related to nutrition, et al. It's relatively hard to sequence. He plans to look for this in the Severely Ill Patient sample. He has not done anything else with it yet, and it is at present just an idea that needs further exploration. He likes to put ideas on PR so you guys can be thinking about things, but often people generalize and conclude too much from what he says. He is careful with his words. He is also very careful not to recommend any treatments. He is not an M.D. And these things are very preliminary. Please be cautious! I try to tell him or read him people's ideas and things they try. He's very interested in your ideas. There are a lot of smart, well-informed people on here! Someone could summarize this tread with bullet points and I'd print it out for him. Please tag me if you do. Thanks!
Janet, let me explain. This actually came about before Ron spoke of mTOR. In the thread about Fluge & Mella research,
@nandixon crafted a hypothesis about the PI3K/Akt/mTORC1 pathway being inhibited. He came to this idea by extrapolating from the F&M study (mTORC1 is upstream of the PDKs that F&M found upregulated). He expanded his theory then, to impaired S1P signaling and low ceramides, which he says is consistent with Naviaux's study.
Here is the first post of his hypothesis:
http://forums.phoenixrising.me/inde...-encephalopathy-cfs.48446/page-12#post-800136
If you follow his posts in that thread you will get the full hypothesis.
@nandixon, if you want to summarise your theory for Ron to read, this is your chance. You'll be better for the job than me.
From this people started experimenting with things that might activate mTORC1, like the Leucine & Glutamine thing Hip did.
And that's where the question about mTOR came from, I believe. And when Ron answered that he thinks mTOR might indeed play a role, that further encouraged us to explore this option. And then in the thread about that Q&A, someone found a paper stating that all antibiotics perscribed for acne work by inhibiting mTORC1 -
http://forums.phoenixrising.me/inde...to-2-21-17-research-update.49749/#post-820778
And then a lot of people came out and said they've been taking antibiotics for acne right before their illness started. Myself included.
So that was a third argument for trying to activate mTORC1. And so here is a thread about how to do it, about BCAAs, cimentidine, florinef, and all the rest of it. Someone wanted to try ketamine, but I don't know if they did already. And so far, quite some people are saying that taking BCAAs or whey protein isolate made their PEM go away.
