• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Holotranscobalamin is only 10-30%...


Senior Member
Just found this simple graph showing the small slice of B12 that is really biologically active versus the rest floating in the serum and unusable.



Interesting, isn't it?

If we add partial methylation blocks, transport and conversion issues etc... I can see why people here (myself included) need B12 by the bucketload to get going.