I had a rather big improvement on antibiotics (maybe from 40% to 70%) - after having tried all sorts of non-drug versions for a decade (with little to show for it). The improvement lasted about five years before another sickness and allergic reaction and lack of pacing pushed me further into severe (maybe around 20% now).
I think like most drugs, it's a difficult risk-benefit analysis and we're shooting in the dark. We have very little concept of the microbiome and what will get killed off or replace it. So we're left with trial and error, but sometimes the errors can do lasting damage.