Shanti1
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Hypercoagulation and low RBC deformability (inability to bend and pass through capillaries) have both been proposed as contributing to ME/CFS symptoms by impeding oxygen delivery to tissues and the brain.
I'm interested in what coagulation tests look like in our group and Erythrocyte Sedimentation Rate (ESR), which tends to be low in pwME, probably due to low red blood cell deformability.
Here is the study from which theories of hypercoagulation are derived: https://pubmed.ncbi.nlm.nih.gov/10695770/
Here is the study showing alterations in RBC in pwME, including low RBC deformability. The abstract also explains how these RBC changes result in a low ESR: https://ashpublications.org/blood/a...rocyte-Deformability-As-a-Potential-Biomarker
Of note, most overt hypercoagulation states will result in an elevated ESR (ref)(ref)(ref)(ref)(ref)
In contrast, pwME tend to have a low ESR, likely due to low RBC deformability. Interestingly, blood hyperviscosity syndromes of all types result in a low ESR. Low RBC deformability is one cause hyperviscosity:
https://www.researchgate.net/public...cosity/link/0c960531ed0dd3724f000000/download (download the free full text)
For those interested, you can also view the results of Cort's 2019 ESR poll here
I'm interested in what coagulation tests look like in our group and Erythrocyte Sedimentation Rate (ESR), which tends to be low in pwME, probably due to low red blood cell deformability.
Here is the study from which theories of hypercoagulation are derived: https://pubmed.ncbi.nlm.nih.gov/10695770/
Here is the study showing alterations in RBC in pwME, including low RBC deformability. The abstract also explains how these RBC changes result in a low ESR: https://ashpublications.org/blood/a...rocyte-Deformability-As-a-Potential-Biomarker
Of note, most overt hypercoagulation states will result in an elevated ESR (ref)(ref)(ref)(ref)(ref)
In contrast, pwME tend to have a low ESR, likely due to low RBC deformability. Interestingly, blood hyperviscosity syndromes of all types result in a low ESR. Low RBC deformability is one cause hyperviscosity:
https://www.researchgate.net/public...cosity/link/0c960531ed0dd3724f000000/download (download the free full text)
For those interested, you can also view the results of Cort's 2019 ESR poll here