Yes, but in much higher doses. Although Dr D J has said that in clinical practise she does feel there is a difference. I should note that I've tried a low dose 200mcg of methylmate and can only tolerate it every other day or even every three days. I think i read somewhere that even if only tolerate small amounts for some reason which I don't understand i might nonetheless tolerate a much higher dose in the form of deplin. Can anyone explain why this would be? Many thanks