Montoya's reseach showing that they didn't have a statistically significant effect at 6 months caused medicine to stop approving antivirals to treat ME. Doctors doing it are off label.
I don't think they are necessary if the checkpoints are not inhibited. Given their expense and the difficulty finding a doctor who is willing to go against the concensus and prescribe them, I'm glad that another approach could be effective, whether it is targeted supplements or a modified DRACO-VTose with caspase 7. The body's normal response to viruses is to kill off the cell with apoptosis and most ME patients develop it after viral infections so this is a great area to research.