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Gut Inflammation In CFS

redo

redo

Senior Member
Messages
874
Ahh. I am reading the thread with my cell. Feels kinda like looking at a map through a keyhole. I didn't read the URL the first time. Got it now, thanks.
 
Wayne

Wayne

Senior Member
Messages
4,308
Location
Ashland, Oregon
Beyond said:
http://www.biomedcentral.com/content/pdf/1743-7075-7-79.pdf
Click to expand...

Beyond, thanks much for posting this. Here's the abstract:
...........................................................

Abstract
Chronic fatigue syndrome (CFS) is a debilitating disease characterized by unexplained disabling fatigue and a combination of accompanying symptoms the pathology of which is incompletely understood. Many CFS patients complain of gut dysfunction. In fact, patients with CFS are more likely to report a previous diagnosis of irritable bowel syndrome (IBS), a common functional disorder of the gut, and experience IBS-related symptoms.

Recently, evidence for interactions between the intestinal microbiota, mucosal barrier function, and the immune system have been shown to play a role in the disorder's pathogenesis.Studies examining the microecology of the gastrointestinal (GI) tract have identified specific microorganisms whose presence appears related to disease; in CFS, a role for altered intestinal microbiota in the pathogenesis of the disease has recently been suggested. Mucosal barrier dysfunction promoting bacterial translocation has also been observed.

Finally, an altered mucosal immune system has been associated with the disease. In this article, we discuss the interplay between these factors in CFS and how they could play a significant role in GI dysfunction by modulating the activity of the enteric nervous system, the intrinsic innervation of the gut.If an altered intestinal microbiota, mucosal barrier dysfunction, and aberrant intestinal immunity contribute to the pathogenesis of CFS, therapeutic efforts to modify gut microbiota could be a means to modulate the development and/or progression of this disorder.

For example, the administration of probiotics could alter the gut microbiota, improve mucosal barrier function, decrease pro-inflammatory cytokines, and have the potential to positively influence mood in patients where both emotional symptoms and inflammatory immune signals are elevated. Probiotics also have the potential to improve gut motility, which is dysfunctional in many CFS patients.
 
MeSci

MeSci

ME/CFS since 1995; activity level 6?
Messages
8,231
Location
Cornwall, UK
Bother - it's from 2010 and I already have it. It's been referred to before on here, and a thread about it was posted in 2010 here.

Maybe a mod could merge the two threads?

It's always good to resurrect papers like this for people who haven't seen them or the earlier discussions.
 
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