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Gut Inflammation In CFS

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by shannah, Oct 13, 2010.

  1. shannah

    shannah Senior Member

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    Gut inflammation in chronic fatigue syndrome
    Shaheen E Lakhan and Annette Kirchgessner

    Nutrition & Metabolism 2010, 7:79doi:10.1186/1743-7075-7-79


    Published: 12 October 2010

    Abstract (provisional)
    Chronic fatigue syndrome (CFS) is a debilitating disease characterized by unexplained disabling fatigue and a combination of accompanying symptoms the pathology of which is incompletely understood. Many CFS patients complain of gut dysfunction. In fact, patients with CFS are more likely to report a previous diagnosis of irritable bowel syndrome (IBS), a common functional disorder of the gut, and experience IBS-related symptoms. Recently, evidence for interactions between the intestinal microbiota, mucosal barrier function, and the immune system have been shown to play a role in the disorder's pathogenesis. Studies examining the microecology of the gastrointestinal (GI) tract have identified specific microorganisms whose presence appears related to disease; in CFS, a role for altered intestinal microbiota in the pathogenesis of the disease has recently been suggested. Mucosal barrier dysfunction promoting bacterial translocation has also been observed. Finally, an altered mucosal immune system has been associated with the disease. In this article, we discuss the interplay between these factors in CFS and how they could play a significant role in GI dysfunction by modulating the activity of the enteric nervous system, the intrinsic innervation of the gut. If an altered intestinal microbiota, mucosal barrier dysfunction, and aberrant intestinal immunity contribute to the pathogenesis of CFS, therapeutic efforts to modify gut microbiota could be a means to modulate the development and/or progression of this disorder. For example, the administration of probiotics could alter the gut microbiota, improve mucosal barrier function, decrease pro-inflammatory cytokines, and have the potential to positively influence mood in patients where both emotional symptoms and inflammatory immune signals are elevated. Probiotics also have the potential to improve gut motility, which is dysfunctional in many CFS patients.
    http://www.nutritionandmetabolism.com/content/7/1/79
    MeSci likes this.
  2. ukme

    ukme Senior Member

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    Thanks Shannah that's really interesting
  3. Enid

    Enid Senior Member

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    Thanks so much for the article. Confirms what one suspected - long ago.
  4. TheMoonIsBlue

    TheMoonIsBlue Senior Member

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    I believe a lot of people with ME/CFS have stomach viruses (enteroviruses) such as the Coxsackie B4 virus. However, no treatment other than Interferon treatment has been suggested to work, and Interferon is not a treatment to be taken lightly, it can have some serious side effects including some reported serious psychological side effects.
  5. shannah

    shannah Senior Member

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    What about Equilibrant?
  6. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    australia (brisbane)
    There are medication called interferon induces that have direct antiviral properties as well as enhancing natural killer cells function and alot less side effects compared to interferon treatment, these are immunovir and cycloferon and will help against a broad range of infections.

    cheers!!!
  7. TheMoonIsBlue

    TheMoonIsBlue Senior Member

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    Hi, I've seen Equilibrant but I haven't tried it. I would like to hear from anyone who has. I don't believe it contains Oxymatrine (sp?) though....which is one of the things Dr. Chia was using for enteroviruses. Something about difficulities in obtaining it from reliable manufacturers. I may be wrong.
  8. Daffodil

    Daffodil Senior Member

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    heap...do you know where to obtain cycloferon?

    thanks
    sue
    xoxox
  9. Snow Leopard

    Snow Leopard Senior Member

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    Equilibrant does contain 'shrubby' sophora root extract (which contains oxymatrine). I have been taking it for over a month, but I haven't been tested for Echovirus or Coxsackie variants as the tests available here are nonspecific.

    Edit - With regards to the original article, it is an interesting review article written by a intelligent guy, who well, likes to write review articles. http://slakhan.gnif.org/publication.php
  10. Dolphin

    Dolphin Senior Member

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  11. Dolphin

    Dolphin Senior Member

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    Thanks for background. I thought it was an interesting review too. I've seen a lot worse review articles in the ME/CFS area over the years. This was right up-to-date and sympathetic. It also explained some of the science and biology - perhaps not necessary for some people but I was a bit hazy on it as I stopped studying biology aged 16. It seemed quite thorough.
  12. Desdinova

    Desdinova Senior Member

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    Suffered from IBS from 1992-1999. Dealt with the Skepticism, disbelief and sarcasm form Doctors and regular folks about my problems. Had to go to the ER at least three times because of it. The third GI I saw diagnosed me so casually by saying "oh you have IBS...... it's a growing problem and is becoming very common." Now since 2006 I have to deal with Skepticism, disbelief and sarcasm form Doctors and regular folks about my medical problems once again. How Ironic, history repeating it's self, you'd think that the medical community would learn.
  13. TheMoonIsBlue

    TheMoonIsBlue Senior Member

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    Is there anything going on anymore with enterovirus research and ME/CFS? Other than Dr. Chia........? (P.S. Isn't EBV considered an enterovirus?) I wonder how many of us have the Coxsackie viruses.....what to do what to do?
  14. leaves

    leaves Senior Member

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  15. Snow Leopard

    Snow Leopard Senior Member

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    EBV is Human-Herpes Virus 4..

    There have been a few other articles mentioned in this article:
    http://jcp.bmjjournals.com/content/61/1/1.full

    See also: articles on post-polio syndrome.
  16. Angela Kennedy

    Angela Kennedy *****

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    Yeah -problem with this article claiming IBS is a 'functional' disorder (as in no discernible organic cause, often used to denote psychogenic explanation).

    IBS is one of the catch-all terms used to denote the doctor doesn't know what's wrong. Diverse signs and symptoms can be deemed IBS- so it's a highly unstable term. That ME/CFS sufferers get this diagnosis is not surprising- because the causes of their bowel disturbances are not being looked for and therefore become 'medically unexplained'.
  17. doug

    doug

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    San Rafael, CA
  18. WillowJ

    WillowJ Senior Member

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    That's a great article--thanks :)
  19. WillowJ

    WillowJ Senior Member

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    In addition to Chia, newer than 2008 would be:

    Zhang L, Gough J, Christmas D, Mattey DL, Richards SC, Main J, Enlander D, Honeybourne D, Ayres JG, Nutt DJ, Kerr JR. "Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis." J Clin Pathol. 2010 Feb;63(2):156-64. Epub 2009 Dec 2. PMID: 19955554

  20. redo

    redo Senior Member

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    Great article. But I can't find the full text. I can only read "Abstract and Introduction". If I google phrases from the article, then subpages pop up, but I can't get it all to read.

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