Genetic results for Methylation (help analysing)

[godlovesatrier]

Hi there,

Can anyone tell me what the following methylation results would mean in terms of supplements? That is what I should and shouldn't be taking? I'm trying b12 injections hydroxocobalamin but after my first 1mg dose I've been hit with terrible fatigue and extreme drowsiness. So I am wondering if it's simply due to a methylation mutation issue. Any help appreciated thanks in advance!

I currently take omega 3, vitamin c and magnesium, q10 and follow an exclusion diet no dairy, no gluten.

 

[Learner1]

Hydroxocobalamin has NO methyl groups which you badly need.

Your homozygous MTHFR SNP reduces your folate pathway by 70% and MTR doubles the need for MB12.

You might check MCV, homocysteine, methylmalonic acid, and serum and RBC folate to verify, but Id guess you'd need significant 5-MTHF (5-15mg) and MB12 (2-10mg) plus appropriate cofactors - magnesium, B2, B6, BAC, glycine, V1, and molybdenum, and maybe potassium. Plus you likely can't get enough BH4 - Kuvan, pteridin, or royal jelly could help with that.

 

[godlovesatrier]

Hi @Learner1

Thanks for the reply. Is there another type of injectable b12 I should try to get?

My last folic acid test was halfway between high and low on the last blood test I got, so that seems ok.

Thanks,

 

[Learner1]

MethylB12, 5mg/ml is the one I have.

 

[Learner1]

What sort of "folic acid"? And, if you start getting enough B12, you'll likely start using foksre a LOT faster.

 

[godlovesatrier]

Well that's the thing the tests don't say what type of folic test it is. It just says folic.

What's foksre?

I did just find a methyl supplement made by biocare which has plenty of folate (not folic) in it and the right form of b12.

https://www.biocare.co.uk/methyl-b-...IXTMzNn0fqqg2YtaZZcaAnkcEALw_wcB&gclsrc=aw.ds