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Genetic results for Methylation (help analysing)

godlovesatrier

Senior Member
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Hi there,

Can anyone tell me what the following methylation results would mean in terms of supplements? That is what I should and shouldn't be taking? I'm trying b12 injections hydroxocobalamin but after my first 1mg dose I've been hit with terrible fatigue and extreme drowsiness. So I am wondering if it's simply due to a methylation mutation issue. Any help appreciated thanks in advance! :)

I currently take omega 3, vitamin c and magnesium, q10 and follow an exclusion diet no dairy, no gluten.

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Learner1

Senior Member
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Hydroxocobalamin has NO methyl groups which you badly need.

Your homozygous MTHFR SNP reduces your folate pathway by 70% and MTR doubles the need for MB12.

You might check MCV, homocysteine, methylmalonic acid, and serum and RBC folate to verify, but Id guess you'd need significant 5-MTHF (5-15mg) and MB12 (2-10mg) plus appropriate cofactors - magnesium, B2, B6, BAC, glycine, V1, and molybdenum, and maybe potassium. Plus you likely can't get enough BH4 - Kuvan, pteridin, or royal jelly could help with that.
 

godlovesatrier

Senior Member
Messages
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442
Location
United Kingdom
Hi @Learner1

Thanks for the reply. Is there another type of injectable b12 I should try to get?

My last folic acid test was halfway between high and low on the last blood test I got, so that seems ok.

Thanks,