Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in ME/CFS: A Pilot Study. Perez et al 2019

[pattismith]

There is useful things in that study if you can filter the signal from the noise. For example, this supports previous research about a 2.5 times times increased frequency of Mannose-Binding Lectin Deficiency in ME/CFS.

I believe the data is pretty consistent across platforms for certain MBL2 SNPs.

Mannose-Binding Lectin Deficiency is the most common immune deficiency worldwide with a prevalence of about 5 to 10%.
https://ghr.nlm.nih.gov/condition/mannose-binding-lectin-deficiency#statistics

But it's so common, that almost nobody knows about it and is treated as it it were an orphan disease. It's a lot more common in certain parts of Africa and has a lot to do with the with the immune response to and severity of Malaria in that region. Common and deleterious.

And it's a risk factor for ME/CFS. I'm sure treatments could be made for it (and I have my own hypotheses for what these treatements might be), but nobody cares.

23andme says I have 2x rs1800450 pathogenic variant (allele frequency 13.89%), so it's probably a factor for my ME/CFS/Fibro....