Frequent IgG subclass and mannose binding lectin deficiency in patients with CFS

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it's strange that your IgG4 result is not more precise....

Do you have IgG4 related disease?
IMD Berlin doesn't measure large values, they are looking for a deficiency. Doctors are telling me that high values don't have any significance. They don't seem to be up-to-date. I also did hyposensitization therapy in the past and could have bumped it up. It's either that there are more IgG4+ plasma B-cells present or normal plasma B-cell count with increased IgG4 secretion. To answer your question: I don't know and healthcare doesn't investigate.
 

anne_likes_red

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MBL2 status seems related to disease severity per this study and some earler ones.

"The present study was designed to conduct a systematic investigation of the interaction of the human humoral PRMs with SARS-CoV-2. We found that PTX3 and MBL bound the SARS-CoV-2 nucleocapsid protein and spike protein, respectively. MBL recognized VoC, had antiviral activity and activated the complement lectin pathway. Genetic polymorphisms at the MBL2 locus were associated with disease severity. Thus, selected fluid-phase PRMs (ante-antibodies) play an essential role in resistance to and pathogenesis of COVID-19, a finding with translational implications."

https://www.nature.com/articles/s41590-021-01114-w