Journeyman
Senior Member
- Messages
- 193
Hi folks,
I'm trying to find out whether I might have the folinic acid intolerance issue and I understand the relevant gene i'm interested to therefore understand is the MTHFS gene.
I've got my 23&Me data, and I've finally figured out how to get the Minor Allele Program to work for me. Now from what I understand the MTHFS gene is on chromosome 15 so I've picked off the 'chromosome 13-22' drop down from the minor allele website here: http://www.ianlogan.co.uk/23andme/minor_allele_data.htm
It spat out the following and sadly I can't find the rs7177659 that is the allele of interest as I try to figure out where I stand on the MTHFS gene... Perhaps this minor allele program doesn't show the results for this gene?
Results:
rs1799952 at Chr13:32912008 gave 'AG' The minor allele is 'A' with a MAF = 0.00182
rs36212784 at Chr13:47471950 gave 'GT' The minor allele is 'T' with a MAF = 0.00365
rs11148233 at Chr13:52594618 gave 'AG' The minor allele is 'G' with a MAF = 0.00457
rs5352 at Chr13:78475230 gave 'CT' The minor allele is 'T' with a MAF = 0.00800.
rs35312232 at Chr14:24724663 gave 'CT' The minor allele is 'T' with a MAF = 0.00800.
rs11853265 at Chr15:41456622 gave 'AG' The minor allele is 'A' with a MAF = 0.00091
rs17269439 at Chr15:59063144 gave 'AC' The minor allele is 'A' with a MAF = 0.00914
rs45517339 at Chr16:2134578 gave 'CT' The minor allele is 'T' with a MAF = 0.00999
rs8176928 at Chr16:3706185 gave 'GG' The minor allele is 'G' with a MAF = 0.00457
rs4986970 at Chr16:67976320 gave 'AT' The minor allele is 'T' with a MAF = 0.00914
rs4319825 at Chr17:19639798 gave 'AG' The minor allele is 'A' with a MAF = 0.00731
rs6355 at Chr17:28548810 gave 'CG' The minor allele is 'G' with a MAF = 0.00639
rs28914827 at Chr17:28549809 gave 'CT' The minor allele is 'T' with a MAF = 0.00639.
rs11655238 at Chr17:29624175 gave 'AG' The minor allele is 'A' with a MAF = 0.00685
rs939346 at Chr17:38252667 gave 'AG' The minor allele is 'G' with a MAF = 0.00502
rs10305278 at Chr17:38599408 gave 'GT' The minor allele is 'T' with a MAF = 0.00731
rs17746949 at Chr18:31324766 gave 'AG' The minor allele is 'A' with a MAF = 0.00822
rs28399448 at Chr19:41352936 gave 'CT' The minor allele is 'T' with a MAF = 0.00999
rs11466310 at Chr19:41861858 gave 'CT' The minor allele is 'T' with a MAF = 0.00776.
rs17004515 at Chr21:44692863 gave 'AC' The minor allele is 'A' with a MAF = 0
rs8142248 at Chr22:46684906 gave 'GT' The minor allele is 'T' with a MAF = 0.00502
The selected level was 0.01
If its the case that the minor allele program won't show this MTHFS relevant gene then please see my results drawn from the raw 23&Me data after doing a search on their site, within my gene for 'MTHFS' :
MTHFS, ST20-MTHFS 80136129 rs685487 A or G AG
MTHFS, ST20-MTHFS 80136288 rs8033649 A or C CC
MTHFS, ST20-MTHFS 80137560 rs8923 C or T TT
MTHFS, ST20-MTHFS 80138571 rs2733103 C or T CC
MTHFS, ST20-MTHFS 80138745 rs16971427 A or C AA
MTHFS, ST20-MTHFS 80141997 rs655473 A or G AA
MTHFS, ST20-MTHFS 80144197 rs17284990 C or T CT
MTHFS, ST20-MTHFS 80154571 rs16971450 A or G AA
MTHFS, ST20-MTHFS 80154982 rs6495446 C or T CC
MTHFS, ST20-MTHFS 80158042 rs7177659 A or C AC
MTHFS, ST20-MTHFS 80158159 rs6495449 A or G GG
MTHFS, ST20-MTHFS 80162265 rs17285431 A or C AA
MTHFS, ST20-MTHFS 80164053 rs6495451 C or T CT
MTHFS, ST20-MTHFS 80165368 rs2586154 A or G GG
MTHFS, ST20-MTHFS 80168282 rs12899781 G or T TT
MTHFS, ST20-MTHFS 80171971 rs16971478 A or G AA
MTHFS, ST20-MTHFS 80172133 rs2586153 C or T CC
MTHFS, ST20-MTHFS 80174388 rs2562744 A or C AC
MTHFS, ST20-MTHFS 80177687 rs2733106 A or G AA
MTHFS, ST20-MTHFS 80178283 rs12438477 A or C AC
MTHFS, ST20-MTHFS 80182050 rs12898642 C or T CT
MTHFS, ST20-MTHFS 80183766 rs2586182 A or C AA
MTHFS, ST20-MTHFS 80184657 rs2733088 A or G AG
MTHFS, ST20-MTHFS 80186340 rs12440798 C or T CT
Page 1 of 1
Am I the same as Rich meaning I should have no problem tolerating folinic acid? I'm SHTM1 +/- too btw.
Thanks in advance you MTHFS guru's!
I'm trying to find out whether I might have the folinic acid intolerance issue and I understand the relevant gene i'm interested to therefore understand is the MTHFS gene.
I've got my 23&Me data, and I've finally figured out how to get the Minor Allele Program to work for me. Now from what I understand the MTHFS gene is on chromosome 15 so I've picked off the 'chromosome 13-22' drop down from the minor allele website here: http://www.ianlogan.co.uk/23andme/minor_allele_data.htm
It spat out the following and sadly I can't find the rs7177659 that is the allele of interest as I try to figure out where I stand on the MTHFS gene... Perhaps this minor allele program doesn't show the results for this gene?
Results:
rs1799952 at Chr13:32912008 gave 'AG' The minor allele is 'A' with a MAF = 0.00182
rs36212784 at Chr13:47471950 gave 'GT' The minor allele is 'T' with a MAF = 0.00365
rs11148233 at Chr13:52594618 gave 'AG' The minor allele is 'G' with a MAF = 0.00457
rs5352 at Chr13:78475230 gave 'CT' The minor allele is 'T' with a MAF = 0.00800.
rs35312232 at Chr14:24724663 gave 'CT' The minor allele is 'T' with a MAF = 0.00800.
rs11853265 at Chr15:41456622 gave 'AG' The minor allele is 'A' with a MAF = 0.00091
rs17269439 at Chr15:59063144 gave 'AC' The minor allele is 'A' with a MAF = 0.00914
rs45517339 at Chr16:2134578 gave 'CT' The minor allele is 'T' with a MAF = 0.00999
rs8176928 at Chr16:3706185 gave 'GG' The minor allele is 'G' with a MAF = 0.00457
rs4986970 at Chr16:67976320 gave 'AT' The minor allele is 'T' with a MAF = 0.00914
rs4319825 at Chr17:19639798 gave 'AG' The minor allele is 'A' with a MAF = 0.00731
rs6355 at Chr17:28548810 gave 'CG' The minor allele is 'G' with a MAF = 0.00639
rs28914827 at Chr17:28549809 gave 'CT' The minor allele is 'T' with a MAF = 0.00639.
rs11655238 at Chr17:29624175 gave 'AG' The minor allele is 'A' with a MAF = 0.00685
rs939346 at Chr17:38252667 gave 'AG' The minor allele is 'G' with a MAF = 0.00502
rs10305278 at Chr17:38599408 gave 'GT' The minor allele is 'T' with a MAF = 0.00731
rs17746949 at Chr18:31324766 gave 'AG' The minor allele is 'A' with a MAF = 0.00822
rs28399448 at Chr19:41352936 gave 'CT' The minor allele is 'T' with a MAF = 0.00999
rs11466310 at Chr19:41861858 gave 'CT' The minor allele is 'T' with a MAF = 0.00776.
rs17004515 at Chr21:44692863 gave 'AC' The minor allele is 'A' with a MAF = 0
rs8142248 at Chr22:46684906 gave 'GT' The minor allele is 'T' with a MAF = 0.00502
The selected level was 0.01
If its the case that the minor allele program won't show this MTHFS relevant gene then please see my results drawn from the raw 23&Me data after doing a search on their site, within my gene for 'MTHFS' :
MTHFS, ST20-MTHFS 80136129 rs685487 A or G AG
MTHFS, ST20-MTHFS 80136288 rs8033649 A or C CC
MTHFS, ST20-MTHFS 80137560 rs8923 C or T TT
MTHFS, ST20-MTHFS 80138571 rs2733103 C or T CC
MTHFS, ST20-MTHFS 80138745 rs16971427 A or C AA
MTHFS, ST20-MTHFS 80141997 rs655473 A or G AA
MTHFS, ST20-MTHFS 80144197 rs17284990 C or T CT
MTHFS, ST20-MTHFS 80154571 rs16971450 A or G AA
MTHFS, ST20-MTHFS 80154982 rs6495446 C or T CC
MTHFS, ST20-MTHFS 80158042 rs7177659 A or C AC
MTHFS, ST20-MTHFS 80158159 rs6495449 A or G GG
MTHFS, ST20-MTHFS 80162265 rs17285431 A or C AA
MTHFS, ST20-MTHFS 80164053 rs6495451 C or T CT
MTHFS, ST20-MTHFS 80165368 rs2586154 A or G GG
MTHFS, ST20-MTHFS 80168282 rs12899781 G or T TT
MTHFS, ST20-MTHFS 80171971 rs16971478 A or G AA
MTHFS, ST20-MTHFS 80172133 rs2586153 C or T CC
MTHFS, ST20-MTHFS 80174388 rs2562744 A or C AC
MTHFS, ST20-MTHFS 80177687 rs2733106 A or G AA
MTHFS, ST20-MTHFS 80178283 rs12438477 A or C AC
MTHFS, ST20-MTHFS 80182050 rs12898642 C or T CT
MTHFS, ST20-MTHFS 80183766 rs2586182 A or C AA
MTHFS, ST20-MTHFS 80184657 rs2733088 A or G AG
MTHFS, ST20-MTHFS 80186340 rs12440798 C or T CT
Page 1 of 1
Am I the same as Rich meaning I should have no problem tolerating folinic acid? I'm SHTM1 +/- too btw.
Thanks in advance you MTHFS guru's!