That's OK, Bluebell, I am. I am crazy, that is. I just couldn't add my results by throwing them in a post. I have everyone's results in a spreadsheet except their tolerance or intolerance to folinic acid. Don't worry, but if you try folinic acid, let us know, because it may do some good in figuring this out. I think you may be right that it's more an SHMT1 issue than an MTHFS issue, but good data crunching will help. BTW, I am SHMT1 (+/+) (AA), unlike any of the others who have posted. And I'm rs7177659 AA like nandixon. So, if if either of these are the culprits, I should be most sensitive. So, now let me throw a wrench in the whole works. I took 800 mcg of folinic acid and the first day I thought "it can't possibly be this that's making me feel so good!" The second and third days I could hardly keep my eyes open. Not so much fatigue as almost narcolepsy (not really, but you get the idea.) Not being a informed as some of the people here, I've been following the AMRI website and was prepared that "energy production will falter" so I'd already planned to add L-carnitine, NADH, and ribose. The 4th and 5th days I did so, and didn't really have any trouble being overly sleepy. Today is the 6th day. I'm thinking the sleepiness may be coming back, but my allergies are so bad that it's hard to tell. For now, I'm saying I'm intolerant, but time will tell. Here's the file.