You certainly aren't irritating me. I just don't agree with some of the conclusions you have reached. Sorry.I think there is an elephant in the room.
If normal, healthy people don't get into trouble when taking 30 mg of methylfolate or mB12, or even higher, why think of overmethylation when taking crumbs?
If one insists on thinking the effects discussed ad nauseum are due to (over)methylation, I think it makes more sense to think of micro level, to tissue specific differences in methylation already present (hyper/hypo; not necessarily related to mfolate/B12 intakes ) instead of the general amount of SAMe.
But hey, who am I... Besides, my view has no practical use other than stating the obvious every persons's different and the advise ad nauseum to be careful.
I don't wish to irritate anybody by questioning the model used, including myself, so I'll shut up.
I seriously question that 30 mg is all perfectly fine for a normal person. What is the standard of judgment? Toxicity? That is a completely different concept than if it produces side effects like high neurotransmitter levels, inflammation (which is a given sorry), insomnia, but also improved energy, vitality, etc. Healthy people are warned about side effects of many b-vitamins. Give a person 3000 mg of pantothenic acid and see what happens. It is not toxic (well except you need extra biotin). But boy many "healthy" people will have trouble sleeping as their adrenals are amped. Again doesn't mean the vitamin is toxic. High levels of b6 can lead to neuropathy. But again it is remarkably non-toxic depending on your definition.
I question the assumption being used here. If the logic is a person is healthy if they can take 30 mg with no effect, I am not sure what to say to that. In fact the simple counter-argument is see what the side effects are of SAMe for people who take 400 mg or more a day. Perfectly healthy people I should add.
Besides what is a healthy normal person anyways? Some of the genes that are sighted have been in linkage disequilibrium for millenia with other genes and occur at high population frequencies. I know most people on these board like to ignore the population frequency arguments that I bring up because they want to some clear cut reason for their issues they can read off their 23andme test. But it is not that simple. There are tons of people walking around with MTHFR and other SNPs. Yet they are healthy. But by definition their reactions to methylfolate have to be different if we think we understand the enzymes and pathways at all. So how does that factor in?
I have studied methylation some in the course of my computational research back in the 90s. I can't claim to be a world-class expert. Yes there is micro control. I tried to give you an analogy with glycine that you can read up about. The methylation controls are more complicated but as chemicals they are in equilibrium with the macro values of the substrates. Where that is exactly reached with a person is up for debate. Scientists routinely manipulate animals to study hypermethylation. And trust me the extreme version is very dehabilitating in those models. The idea that only the bad genes will be silenced is not correct. Not only not correct. Not possible. Nor is the modulation be uniform or high methylation = death which it obviously does not.
In summary I don't agree with the healthy person = 30 mg with no effect. Toxic does not equal no effect. Toxicity is something different. Check out what happens to perfectly healthy people who take significant doses of SAMe. It is a perfect example since most people take SAMe for their joints where ostensibly other things are generally ok (as much as they can be with modern diets and lifestyle and lack of exercise I suppose).
I side with Adreno here. There is no reason imo to take really high doses unless you are actually getting demonstrable benefit from it. At some point I wager the really high doses are more about CNS symptom relief and dealing with CNS problems via large diffusion gradients. Those of us without B12 deficiency or folate insufficiency induced CNS defects won't benefit from those doses. And in fact the pressure on neurotransmitters, inflammation, potassium and other systems will make things potentially very unstable. i.e. great one moment, feeling bad a few hours later.
On the other hand I agree wholeheartedly that there is something very contradictory going when people react to "crumbs" as you put it, so violently. I don't know what to say there. Theoretically someone should not react really bad to 20 mcg of methylfolate but then not have problems eating meat. Couple of portions of animal flesh and they get the same amount of methylfolate. Also all the talk about folic and folinic acid. If all goes well those roads should lead to increased methyfolate production. Isn't that the point of the folate cycle modulo the purine / DNA synthesis?
Anyways, best of luck as you work out your own protocol. Hope you are continuing to get stronger