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FolaPro and various folate potency?

sregan

Senior Member
Messages
703
Location
Southeast
I'm just about to finish my bottle of Folapro and have finally run out of my "glass bottle" of Jarrow MB12.

I can say that on my latest run of SMP I did NOT have the "brightening" I had the other times where I felt super good for at least a few days. Today I actualy felt very wired and agitated. I decided to take 200 mcg of Jarrow MethylFolate (QuatraFolic) with some Enzymatic MB12 and felt much better immediately.

I also have a bottle (unopened) of Solgr Metafolin at the house.

So my question is of the various forms why would the L-5-MTHF perhaps not be as effective for me as the (6S)-5-methyltetrahydrofolic acid (Jarrow) and possibly L-methylfolate-Metafolin (Solgar).

http://mthfr.net/l-methylfolate-methylfolate-5-mthf/2012/04/05/
seems to think the %L_MTHF == the 6S_L_MTHF

Maybe the potency of my Folapro is questionable. Is it possible my body wants the (6S)-5-methyltetrahydrofolic acid preferably?
 
Last edited:

PeterPositive

Senior Member
Messages
1,426
According to this page:
http://methy-life-site-testing.weebly.com/methylfolate-types.html

it seems that Metafolin is 40% more potent than Quatrefolic. See the table where it indicates that 1mg Metafolin equals 1.4mg Quatrefolic. The reason is the absorption rate which is higher in Metafolin (~76%) vs Quatrefolic (~56%).

From a subjective point of view I've tried both forms and didn't find particular differences. I also tried sublingual Quatrefolic (SeekingHealth) and did not do well on it, feeling super anxious and wired. I suspect it gets in the system too quickly and overstimulates my nervous system. Even at 800-1000mcg is too much for me. On the other hand I can tolerate 2000mcg of Metafolin without problems.

cheers
 

PeterPositive

Senior Member
Messages
1,426
Subjectively I feel quatrefolic is more potent, it certainly feels more stimulating than metafolin.
Out of curiosity do you take it orally or sublingually?
I didn't find any differences with oral administration but definitely the sublingual Quatrefolic was highly stimulating for me, way too much.
 

Critterina

Senior Member
Messages
1,238
Location
Arizona, USA
This is timely! Thanks @adreno and @PeterPositive !
I just switched my Solgar for Piping Rock, both Metafolin, and have been feeling a lack of affect, wondering if it was due to the brands. Maybe I'll go back to Solgar first, then try Quatrefolic. So many excursions!