Hi all,
Its been like 5 years of fatigue and its getting worse... There is nothing on blood tests and doctors have no idea too. Endocrinologist confirmed CFS and proposed that I try synthetic AVP hormone which I refuse to do. Fatigue and breathing problems are ruining my life...
Some background info:
I'm 40, 112KG, 6'1 male. Abt 5 years ago I did a diet for abt 2-3 months - no carbs, no salt and I am w/o gallbladder so maybe I was not absorbing fats either. Bodybuilding exercises 3-4 time a week, some strong multivitamines and drinking every night. Until one night of drinking when I urinated like every 5 minutes and a lot! overall maybe 10-15 times.. And than fatigue came, it was uncomfortable to stand upright, and spending a lot of time in bed. I tried to get better with B12, B-Right, CoQ10, Adrenal Optimizer.. Schisandra got me going again and I was feeling way better. Untill I started Pantethine, which gave me a bit of energy but also made me very worm and sweating all night. I could not sleep for maybe 3 months. I started drinking way more water and urinating way more than ever in my life.. Some periods have been a bit better after that and I have been able to ride a bicycle 10-15km at times or walk 10 km per day. Brain fog never really clears. Some 2-3 years ago I started feeling breathless when walking uphill or upping the intensity when cycling. If I do not stop immediately when I feel it coming - I get worst panic attack one can imagine with throat tightness (as much as I can't even drink water), stomach distention and hyperventilation that brings no relief. This happened a couple of times when I was just walking around the block last few days. I had to decrease the temp so it goes away.. but now I'm scared to even go to the store. Cardiologist finds nothing..
I eat a little meat. If I eat too much I start urinating too much, get constipated and depressed. SO I eat a lot of pasta..and still have to drink a lot of water all day and almost every day I start urinating in the early evening. That stops with dinner. After some meals I also have to drink a lot of water or I get breathless even from speaking. Especially after dinner when I have been urinating I also get fast heartbeat, lightheaded and very warm. So dinner, water, good sleep, more water in the AM not much urination, lunch, more water, 4-5PM urination starts.. I cant go anywhere without water and place to pee. High potassium foods seem to also make me pee too much.
Nothing much in the labs:
-Urine osmolarity was fine.
-Serum osmolarity showed 330 (280-295) on one test and than 275 on another where AVP was in range but low for this specific osmolarity.
- Homocysteine is almost 15 and doc does not care at all.
-Hemoglobin at 165 (120-180) with erythrocytes count at 6.18 (5.9 upper limit) MCV below range and decreasing. B12 at 290 (140-400).
-Electrolytes are fine.
-Blood gas, ammonia, lactate - nothing really..
-ACTH, Renin, Aldosterone, Free Testosterone (close to up limit), serum cortisol, Insulin, Glucose (close to high limit) are OK..
Breathing seems OK like 2 hours after food when I drank enough water.. until I make a physical effort...
This all feels like some dehydration/low blood volume/inability of potassium to get into the cell..I feel like I am better on days when I eat more pasta or pizza and retain a bit more water from carbs and salt but in a day or two I will piss it no matter what I do. On days when I eat more fruit I will piss a lot more and will be drinking a lot more water and I get the feeling as if I washed out the salt from my body - some nasty feeling in the stomach and mouth..
Last thing I tried was L-carnitine fumarate with 2.5mg B1 in it. Can't really say it did anything.
No ideas what to do further..
Advice will be greatly appreciated!
Thanks!
P.S. I know its TLDR. tried to keep it as short as possible.
Its been like 5 years of fatigue and its getting worse... There is nothing on blood tests and doctors have no idea too. Endocrinologist confirmed CFS and proposed that I try synthetic AVP hormone which I refuse to do. Fatigue and breathing problems are ruining my life...
Some background info:
I'm 40, 112KG, 6'1 male. Abt 5 years ago I did a diet for abt 2-3 months - no carbs, no salt and I am w/o gallbladder so maybe I was not absorbing fats either. Bodybuilding exercises 3-4 time a week, some strong multivitamines and drinking every night. Until one night of drinking when I urinated like every 5 minutes and a lot! overall maybe 10-15 times.. And than fatigue came, it was uncomfortable to stand upright, and spending a lot of time in bed. I tried to get better with B12, B-Right, CoQ10, Adrenal Optimizer.. Schisandra got me going again and I was feeling way better. Untill I started Pantethine, which gave me a bit of energy but also made me very worm and sweating all night. I could not sleep for maybe 3 months. I started drinking way more water and urinating way more than ever in my life.. Some periods have been a bit better after that and I have been able to ride a bicycle 10-15km at times or walk 10 km per day. Brain fog never really clears. Some 2-3 years ago I started feeling breathless when walking uphill or upping the intensity when cycling. If I do not stop immediately when I feel it coming - I get worst panic attack one can imagine with throat tightness (as much as I can't even drink water), stomach distention and hyperventilation that brings no relief. This happened a couple of times when I was just walking around the block last few days. I had to decrease the temp so it goes away.. but now I'm scared to even go to the store. Cardiologist finds nothing..
I eat a little meat. If I eat too much I start urinating too much, get constipated and depressed. SO I eat a lot of pasta..and still have to drink a lot of water all day and almost every day I start urinating in the early evening. That stops with dinner. After some meals I also have to drink a lot of water or I get breathless even from speaking. Especially after dinner when I have been urinating I also get fast heartbeat, lightheaded and very warm. So dinner, water, good sleep, more water in the AM not much urination, lunch, more water, 4-5PM urination starts.. I cant go anywhere without water and place to pee. High potassium foods seem to also make me pee too much.
Nothing much in the labs:
-Urine osmolarity was fine.
-Serum osmolarity showed 330 (280-295) on one test and than 275 on another where AVP was in range but low for this specific osmolarity.
- Homocysteine is almost 15 and doc does not care at all.
-Hemoglobin at 165 (120-180) with erythrocytes count at 6.18 (5.9 upper limit) MCV below range and decreasing. B12 at 290 (140-400).
-Electrolytes are fine.
-Blood gas, ammonia, lactate - nothing really..
-ACTH, Renin, Aldosterone, Free Testosterone (close to up limit), serum cortisol, Insulin, Glucose (close to high limit) are OK..
Breathing seems OK like 2 hours after food when I drank enough water.. until I make a physical effort...
This all feels like some dehydration/low blood volume/inability of potassium to get into the cell..I feel like I am better on days when I eat more pasta or pizza and retain a bit more water from carbs and salt but in a day or two I will piss it no matter what I do. On days when I eat more fruit I will piss a lot more and will be drinking a lot more water and I get the feeling as if I washed out the salt from my body - some nasty feeling in the stomach and mouth..
Last thing I tried was L-carnitine fumarate with 2.5mg B1 in it. Can't really say it did anything.
No ideas what to do further..
Advice will be greatly appreciated!
Thanks!
P.S. I know its TLDR. tried to keep it as short as possible.