Several groups, including Scheibenbogen's, have reported finding autoantibodies against neurotransmitter receptor antigens in people with ME/CFS.
People with ME/CFS are also more likely to have genetic risk factors associated with autoimmunity and personal and/or family histories of autoimmune conditions. And, clinical trials have demonstrated early success with various immunomodulatory treatments in subsets of people with ME/CFS, including endoxan, rituximab, and immunoadsorption.
In a comparison of ME/CFS patients with 201 healthy controls, significant associations were seen with two specific autoimmunity-related risk alleles only in the ME/CFS patients who reported acute onset of disease with an infection but not in those with ME/CFS without infection-triggered onset or the controls.
In a 2020 paper, Scheibenbogen and pharmacologist Klaus Wirth presented a "unifying hypothesis" of ME/CFS pathophysiology based on the finding of elevations in autoantibodies against beta2-adrenergic receptors and muscarinic acetylcholine receptors in some individuals with the condition.
Rituximab: Work on infusions of the B-cell depleting agent has been conducted by Norwegian researchers beginning in 2011 with a small randomized trial and an open-label, phase 2 study in 2015, both showing clinical responses in ME/CFS. However, a subsequent phase 3, randomized clinical trial of 151 patients, again diagnosed using the Canadian criteria, was negative. There are several possible explanations for this, Scheibenbogen noted. For one, the maintenance dose had to be reduced because of a lack of financial support. "This was probably critical. The lower dose was insufficient to adequately deplete B cells."
this is just about fatigue, but says it's present in 80% of patientsQuestion. I would appreciate information on: I can´t find any research paper regarding CIDP relating to ME/CSF?
In some people, particularly with fibromyalgia:Is “chronic inflammatory demyelinating polyneuropathy” (CIDP) a part of ME/CSF?
Yes.Can CIDP also be considered a chronic form of Guillain-Barré syndrome?
this is just about fatigue, but says it's present in 80% of patients
In some people, particularly with fibromyalgia: