I'm looking at my 23andMe data as well, though I have so far only looked at COL3A1. I don't have any identified as DD, II, or DI...
but I did find that SNP rs1801184 has been linked to vascular EDS testing as a possible indicator
What I don't know is if I'm reading this correctly?
Gene: COL3A1
Position: 189864582
SNP: rs1801184
Possible values: C or T
My values: CC
- per dbSNP, TT is normal; CC is not rare; but when searched in PubMed/Google Scholar T>C is linked with Vascular EDS.
----- I've looked at a high level at EDS and threw it out because a lot of the visible physical symptoms don't seem to apply. And I certainly don't have hypermobility; although I am a bit more flexible than most people, no where near what is described in a lot of the EDS literature.
And then I just got back from a colonoscopy where they found several pockets of diverticulosis. Nothing to worry about, they said, that's really common if you have constipation. Only, I NEVER, EVER, EVER have constipation. NEVER. I spend 80% of my days on the pot from chronic diahrrea... so I looked at one of the other causes which includes vascular EDS. AND when I look at vascular EDS, it lists several side effects that my mother went through... she was diagnosed with Fibromyalgia which I believe was either misdiagnosed ME/CFS or comorbid; but suffered several anuerysms (weak arteries), thin skin that bruised and tore easily, early onset varicose veins that re-occurred multiple times after surgery, pelvic floor prolapse (which might be linked but isn't considered diagnostic) and actually died of inner cranial bleeding (weak blood vessels).
While I don't think diverculosis is all that telling, I suffer frequently with torn tendons and I see the chiropractor ALL THE TIME because my back is constantly sublaxing even after regular treatment. To the point where they keep referring me to a new chiropractor because it's not normal to not stabilize after nth year of considerable treatment to reach a point where the adjustment can last longer than a day or two. As well as spontaneous dislocation of ribs multiple times - weak collagen seems like it might be a link. If you add my mother's history, it feels like more of a link.
So, now... I've seen links to the SNP to Vascular EDS. If I have the 'abnormal' gene I think I want to take it to a doctor. But, I can't be sure I'm following things right from looking at 23andMe (I've misunderstood stuff from them often)...
What do you think my next steps might be???