Aubry
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I reached small remission in 2015 during oral Clindamycin pulsed for gut dysbiosis/sibo. Very hard to achieve this result nowadays but I keep hoping.
Dysbiosis Treatment with ABX, KDM
- Thread starter Banana94
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Aubry
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KDM said for now this is all he can do :/ Because there is some mechanism broken (JAK1 pathway) so inflammation of gut don't stop. Only thing he can do is try to modulate the small and large intestines with herbs or antibiotics + probiotics (reduce overgrowth) in order to have a proper immune respons and no chronic immune activation which makes us ill. In 2019 the JAK1 inhibitor will be available on the market and then we all can cure he said. It keeps raining and all we can do is keep pumping the water away...
Daffodil
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:::doing a dance, waiting for 2019::::
Are you on a low carb diet aubry? This can also reduce unflammation in the gut..
bertiedog
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Has anyone ever mentioned the role of serotonin in the gut? My migraine specialist mentioned it to me today saying that what I thought might be leaky gut symptoms during a severe migraine attack he thought it far more likely to be the role that serotonin plays in a migraine as it is also produced in the gut and can disrupt its function?
Just a thought I was having.
Pam
Just a thought I was having.
Pam
KDM did. I´m lucky not to have symptoms related to low serotonin, but I know from other patients of KDM that he is well aware of this connection and takes it into consideration as of his protocols.
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Daffodil
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KDM says we aren't making serotonin ( or maybe much of it?). I forget the pathway that is involved.....
aquariusgirl
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snowathlete... have you checked to see if you have the FUT2 genes? associated with UC IIRC.......
JaimeS
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I went into studying serotonin early on, because I had such drastic responses to serotinergic precursors like 5-HTP.
1) The serotonin in the general bloodstream has zero to do with the serotonin behind the blood-brain barrier.
2) Your serotonin may be low, but if your receptors have increased sensitivity, then it may not be something you need to increase.
3) Patients may have serotonin autoantibodies, which makes increasing serotonin problematic (one study found 2/3 of patients in a decent-sized cohort had autoantibodies to serotonin).
4) Check your SNPs. If you break down serotonin slowly, low may be more normal for you.
Dont wanna talk bad about KDM. He's a good doctor. But it seems like he often announced that he found the reason of me/cfs. He also doesnt care about low carb diets and methylation support (except hydroxoB12) which has helped many PWME.
Would really appreciate if he found the reason and has a treatment.
Jesse2233
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This seems like something that deserves it's own thread. Wonder if KDM is referring to Ruxolitinib
Marc_NL
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I read in an interview with a SIBO-researcher that they don't recommend going completely low carb when you're taking antibiotics for SIBO. Because most of the antibiotics work on the mechanism of disrupting growth and replication in bacteria, it's better to feed the bacteria when you're trying to kill them. Happy bacteria are apparently easier to kill.
I tried low carb, didn't work for me. It was pretty hard to do with my food intolerances for egg, soy, casein and several nuts.
Aubry
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Aubry
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I see the JAK inhibitor doesn't have influence on IL-8 apparently.... Which is often elevated in ME/CFS/ ... Lyme ... and defined mostly as herxing
Interesting. Do you have a link? Thanks!
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Chris kresser and mark pimental or pimentel advocate prebiotics with sibo treatment. Otherwise the bacteria go into survival mode, they can go without food for a very long time.
So you get them to come out to eat, guar gum Kresser uses, then zap them with the antimicrobials. I assume antibiotics would be the same.
It's an easy Google search.
So you get them to come out to eat, guar gum Kresser uses, then zap them with the antimicrobials. I assume antibiotics would be the same.
It's an easy Google search.
Update:
After 2 months of Azithromycin and 3 moths of Xifaxan (15d/month) my Bacteroides went from 30% to 46%!!
So in my opinion KDM's treatment completely failed.
All he said was: We try Azithromycin.
I insisted that I already had this, and gives me bad diarreha..
Than he told me he will think aboute it and will prescribes me some other ABX.
I don't no which one. It's hard to get a word out of his mouth!
Does anybody has the same experiences with bactericides overgrowth? Is there another treatment like diet?
I don't no if I should take any ABX fore the gut, it doesn't seem to be very successful? Other experiences?
After 2 months of Azithromycin and 3 moths of Xifaxan (15d/month) my Bacteroides went from 30% to 46%!!
So in my opinion KDM's treatment completely failed.
All he said was: We try Azithromycin.
I insisted that I already had this, and gives me bad diarreha..
Than he told me he will think aboute it and will prescribes me some other ABX.
I don't no which one. It's hard to get a word out of his mouth!
Does anybody has the same experiences with bactericides overgrowth? Is there another treatment like diet?
I don't no if I should take any ABX fore the gut, it doesn't seem to be very successful? Other experiences?
Aubry
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You should get metronidazole, ornidazole, tinidazole antibiotic class to address this high bacteroides