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@Learner1 , would you expand on this please? Are you talking about excess iron or deficient iron, or ?? Also, how does ferritin factor in? Do things change when you do high dose C orally vs, IV? I would appreciate your input since you seem to know about this and I am considering the high does C but do have issues with ferritin. Thank you.Additionally, before doing IV C it is essential to determine . . . iron status or mitochondrial damage and/or death may result.
@Wayne , noting that treatment is individualized, do you have any information on his/your guidance on how long VitC/hydrocortizone therapy should be given? These levels seem to be excessive for long-term use, but I'm thinking one or two weeks to attempt to recharge cellular levels.As caring for patients with chronic infections and chronic diseases is highly individualized, there can be no fixed recommendations. Availability, convenience, and expense are important dictating factors in how often someone can receive vitamin C infusions. When this is an early part of a long-term treatment protocol, the recommendations noted for acute infections can be employed, and after a couple weeks, the oral vitamin C/hydrocortisone approach can be adopted. When vitamin C infusions are given intermittently but indefinitely, as one or more times monthly for a cancer patient, the hydrocortisone can always be added.Many patients can benefit from simply taking 5 mg of hydrocortisone orally every time they take their oral form of vitamin C, up to three times daily (15 mg of hydrocortisone total per day). However, all of these possibilities can only be realized with the guidance of a physician or other health care professional who is closely following the clinical response and serial blood testing of a given patient, and who is able to prescribe the oral hydrocortisone tablets. The potential variations in the application of vitamin C with hydrocortisone are numerous.
My thanks to @Learner1 , for bringing up this subject. I am going to give VitC/hydrocortisone a trial.A final possibility is that the megadoses of vitamin C induced some redistribution of body iron stores that masked an actual increase in total body iron. In patients with iron overload and secondary ascorbic acid deficiency, parenteral ascorbic acid promotes iron release from the reticuloendothelial cell,26,27 which is the immediate precursor compartment for circulating ferritin. There was a tendency for serum ferritin levels to fall in iron-replete subjects during the early part of the study (Fig 3), which is consistent with some redistribution from reticuloendothelial stores. However, our subjects were neither iron loaded nor ascorbic acid depleted. Furthermore, we have been unable to demonstrate any acute effects on serum iron or serum ferritin levels when normal subjects are given 500 mg ascorbic acid three times daily for 14 days (Fig 3). A final point is that some initial redistribution of body iron stores would not obscure a long-term effect on serum ferritin levels.
I'm talking about excess iron. Ferritin is the typical measure of iron status, although it's an "acute phase reactant" and can be high due to inflammation rather than just measuring iron, so it's good to be thoughtful when interpreting it. A good idea is also to do a full iron panel, which should lead one to the correct conclusion.@Learner1 , would you expand on this please? Are you talking about excess iron or deficient iron, or ?? Also, how does ferritin factor in? Do things change when you do high dose C orally vs, IV? I would appreciate your input since you seem to know about this and I am considering the high does C but do have issues with ferritin. Thank you.
@Wayne , noting that treatment is individualized, do you have any information on his/your guidance on how long VitC/hydrocortizone therapy should be given?