Jesse2233
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Dr Paul Marik (of Sentara Norfolk General Hospital) has recently developed a novel treatment protocol for life threatening sepsis.
[Edit: full protocol]
Given the latest research, I can't help but wonder if this might be an effective treatment for ME/CFS.
At the recent OMF Stanford Symposium Dr Wenzhong Xiao indicated that gene expression data matches ME/CFS more closely to SIRS than any other disease. Drs Jose Montoya and Kenny DeMeirleir have made similar statements. When I spoke to KDM earlier this year he told me ME is essentially a low grade chronic sepsis.
Obviously these treatments have been used individually in many ME patients, but Dr Marik has shown that the protocol's true benefit for SIRS comes from the unique combination.
My layman's guess at a mechanism of action...
Hydrocortisone lowers systemic inflammation, Vitamin C fights any underlying infection / acts as an antioxidant, Thiamine supercharges metabolism to fuel the process.
Has anyone tried this combo or heard of success with it? It seems reasonably safe and low cost
Of course SIRS is not ME, they are distinct in their presentation and prognosis, but the similarities are too close to ignore
Tagging
@Janet Dafoe (Rose49) and @JaimeS in case this is useful to Ron
[Edit: full protocol]
- IV Vitamin C (1.5 gm every 6 hours for 4 days)
Infused over 30 to 60 minutes and mixed in 100ml normal saline / D5W in water
- IV Thiamine (200 mg every 12 hours for 4 days)
Infused over 30 minutes 50 ml of either normal saline / D5W following IV Vitamin C
- IV Hydrocortisone (50 mg every 6 hours for 7 days followed w/ 3 day taper)
The breakthrough came as Dr. Marik struggled to save a woman dying from overwhelming sepsis. He had recently read about vitamin C as a potential treatment for sepsis, and he recalled that steroids, a common treatment for sepsis, might work well in concert with the vitamin C.
Aware that both were safe and would not harm the patient, he gave her the vitamin C and steroid combination intravenously.
Within hours, his patient was recovering. Two days later she was well enough to leave the ICU.
Dr. Marik and is colleagues were astonished. “We said, ‘What just happened?’”
In the following days they used the combination therapy on two more patients seemingly destined to die of sepsis. Twice more the patients recovered. Dr. Marik and his team quickly adopted the combination therapy as standard practice.
http://www.evms.edu/about_evms/admi...ations/issue_9_4/has-sepsis-met-its-match.php
Given the latest research, I can't help but wonder if this might be an effective treatment for ME/CFS.
At the recent OMF Stanford Symposium Dr Wenzhong Xiao indicated that gene expression data matches ME/CFS more closely to SIRS than any other disease. Drs Jose Montoya and Kenny DeMeirleir have made similar statements. When I spoke to KDM earlier this year he told me ME is essentially a low grade chronic sepsis.
Obviously these treatments have been used individually in many ME patients, but Dr Marik has shown that the protocol's true benefit for SIRS comes from the unique combination.
To strengthen his case and to allay his own apprehensions that this was too good to be true, Dr. Marik worked with colleagues to study the interaction in a lab setting. Two separate biological tests proved that vitamin C and steroids were effective against sepsis — but only when used together.
My layman's guess at a mechanism of action...
Hydrocortisone lowers systemic inflammation, Vitamin C fights any underlying infection / acts as an antioxidant, Thiamine supercharges metabolism to fuel the process.
Has anyone tried this combo or heard of success with it? It seems reasonably safe and low cost
Of course SIRS is not ME, they are distinct in their presentation and prognosis, but the similarities are too close to ignore
Tagging
@Janet Dafoe (Rose49) and @JaimeS in case this is useful to Ron
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