Dr Paul Marik's Sepsis/SIRS Protocol for ME/CFS? (Vit C / Hydrocortisone / Thiamine)

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I've recently done lots of reading on the involvement of H2S in sepsis. It all revolves around the blood vessel endothelium. H2S plays a role in good blood circulation and it also plays a role in inflammatory processes in sepsis. I also found a nutrigenomics guy who thinks the (mercaptopyruvate aided) production of H2S is involved in CFS. I think most mercaptopyruvate is in blood vessels.

Apparently more thiosulfate in the blood means reduced inflammation in sepsis in rats. I also found out that sodium thiosulfate is used to remove cyanide from the body and that thiamine (also in the Marik protocol) helps with this. Holistic people are using sodium thiosulfate to chelate heavy metals.

I'd like to see new sepsis (or CFS) research that involves sodium thiosulfate and thiamine.

I take a high potency dose of Sulphur (homeopathic) as needed (once a week or once a month) and I avoid high glyphosate foods and I'm so healthy I forget to take my probiotics. (I had to take oregano oil during the healing process to kill the systemic candida - otherwise I wouldn't have gotten better).

I got that awful flu this year and the sulphur brought my temp up from 96.8F - to 99.5F every time I took it.
 

Learner1

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Hydrogen sulfide problems are related to issues with methylation, inadequate transsulfuration nutrients, and gut dysbiosis.

Optimizing methylation and the transsulfuration pathway and improving one's microbiome balance are essential to balancing H2S in one's system.
 
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Thanks, that's good information. I think this is about more than nutrition - it's about broken signals. Fixing gut dysbiosis has never done anything for me. I was candida free for 10 years and as soon as I included a tiny bit of sugar in my diet everything came back. I have taken massive amounts of probiotics for 20+ years and I started forgetting to take them last week after i took the high potency sulphur.

The H2S and thiosulfate act as signals in the blood. When I dissolve the elemental sulfur under my tongue it goes into my blood and probably makes hydrogen sulfide and thiosulfate - but only a tiny bit. It makes enough to act as a signal but that's it.

Many experts compare chronic fatigue to chronic sepsis and having experienced it, i agree. Thiosulfate apparently helped some septic rats and it may be helping me too.

I'd like to see if sodium thiosulfate is a possible treatment for CFS. If there's anybody you can talk to, please do.

overview of H2S and sepsis research in here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562801/

I'm not taking any supplements - just multivitamins, vitamin c, b complex, and probiotics. So there's no confusion about what's improving my health right now.