I took Valcyte for two months and experienced horrendous side effects. All of my symptoms became much worse and I lost over half of my hair. I had planned to keep taking it, however, hoping to tough it out in hopes of eventually seeing improvement. However, after 2 months, my insurance refused to pay for it-thank God. BTW-I also take cortef and had for several months prior to starting the Valcyte. I personally feel that detox issues need to be addressed before doing any heavy duty anti-fectious treatment, as our bodies are already in such a weakened state. The only anti-fectious treatment that I've been able to tolerate is Immunovir. I experienced 3 months of significant improvement while taking it (I took it for 5 months). Unfortunately, it stopped working after that, not sure why, though I plan to try it again at some point.