Just want to chime back in here to report that I am having a sort of amazing response to Valtrex. I don't know if this response will last. The first time I was on Valtrex, I could feel an improvement at the 3-week mark. I recently restarted Valtrex after a very rough year off of anti-virals, it's been about three weeks and this time around the response is that I am not crashing...knock on wood. I'm still dealing with dysautonomia/POTS and need to rest along with taking naps. But I've been able to do activities without crashing (i.e. wash a car inside and out, hang out with friends for hours and wake up fine the next morning). I don't have answers for any of this, just want to share my experience. I have not attempted an exercise challenge, as I'm just enjoying being able to be active again...and showering regularly, doing laundry, etc. I should mention that between 2012-part of 2016, I was in a quasi-remission. I don't know if a quasi-remission is what this is, but I will take every solid good day I can get and just hope it lasts. I am still having sore/weak muscles (and muscle spasms) at times and the other morning I woke up and swore I was getting a cold, but all symptoms passed by the afternoon. I even had a fever over 100.