doing better, wondering why...

Viala

Senior Member
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853
Yes, this. My vote is still on the lithium.

The only way to know is to cross check it by pausing supplementation and testing if the effect will go on. If it's a combination it will take more time. Then there's the fact that some things work well in the beginning and then they work differently later on, getting better can also be the effect of what we did long term prior to introducing these changes. Or it's the lithium and it will be easy.
 

pamojja

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The only way to know is to cross check it by pausing supplementation and testing if the effect will go on

I think if lithium helps, depends on many factors, and therefore might in some cases, while others not. If I cross-check my supplemental lithium intake (mainly from lithium containing mineral water, some orotate), it at least didn't hinder my remissions. Not considering all other vitamins, amino and fatty acids, as well as plant-extracts.

minerals.png

Marked in orange are the onsets of main conditions, and in lighter yellow their remissions (first column): 1 = PAD, 2 = COPD, 3 = PEMs.

2021, not being able to sun-bath for 2 winters on an India beach, slight legs pains from 1 returned, though far from the severity as with the original walking-disability. Before remission, my walking-disabilty improved already to 2 hrs painfree walking, undone by 2 in 2012 again. 4 = for the first time rheumatoid arthritis, already ceased with upping anti-inflammatory plant extracts again.

If one checks the 10th year, 2018, one can see many minerals more clearly associated with PEMs remission, than Lithium alone.

All are the actual elemental mineral weights, except Hydrogencarbonate (including other bicarbonates). Since I don't eat processed food, Sodium includes added salt (missing some in local food on my almost yearly India vacations, and the first years). When I calculated my dietary potassium intake the first 3 years, it was at 4.1 g/d additional, Na at 1.9, Ca at 1.1, and Mg at 0.6 g/d.
 
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Viala

Senior Member
Messages
853
I think if lithium helps, depends on many factors, and therefore might in some cases, while others not. If I cross-check my supplemental lithium intake (mainly from lithium containing mineral water, some orotate), it at least didn't hinder my remissions. Not considering all other vitamins, amino and fatty acids, as well as plant-extracts.

In general I think that lithium orotate is safe to use and remission friendly, I was a bit reluctant thinking that it could dampen dopamine too much, but from what I've read is it has more regulatory effect and my experience confirms that as well. When I first tried it years back, it created strong anhedonia, so it can be too much sometimes. It seems that it improved my fats metabolism, it helped with inflammation probably via reducing arachidonic acid and improving GABA.

I see that I am not alone in the spreadsheet craze lol.

The wildest thing I discovered is that a single nutrient can alter how other function and interact, when a dose is above or under a sweet spot threshold. That gives so many variables and I already see that you take much more and also much less minerals than I take.
 

pamojja

Senior Member
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2,782
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Austria
and also much less minerals than I take.

And I thought, probably none exceeds my intake, necessary for me. In which minerals you differ the most?

..a single nutrient can alter how other function and interact, when a dose is above or under a sweet spot threshold.

One can see it, for example, in the above spreadsheet. When I tried to follow the common advice, to balance each 15 mg of zinc with 1 mg of copper. Which backfired in my case badly, and couldn't correct to optimal blood levels again.

The only other incident was with choline, where I couldn't tolerate more than 500 mg/d, without causing jaw-tension. Gradually, intolerance went down to above 300 mg/d. At which I doubled my inositol intake, and which seems to have been the missing co-factor for tolerating much more choline again.

vitamins.png

Above including R-5-P, niacinamide, citicoline, pyridoxin, pantethine, adenosyl-, tocotrienols, K2-mk7, etc.

I see that I am not alone in the spreadsheet craze lol.

I would love to do it without tedious accounting. But I can't see a way, other than spreadsheets, to supplement comprehensively not in a haphazard way and possibly dangerous way. Only documenting and comparing with lab results, does allow finding correlations afterward. Not obvious through symptoms alone. And to adjust doses.
 
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Viala

Senior Member
Messages
853
And I thought, probably none exceeds my intake, necessary for me. In which minerals you differ the most?

Same thoughts here. I take more copper, chromium, molybdenum, manganese, some x10, then less zinc, RDA amount of iodine now, definitely less magnesium. Is that 2g by the way, how is that even possible. From the routes less taken I did boron and copper loading that highly exceeded the norms. Boron helped, copper was painful but increased stamina somewhat.

You definitely top me with vitamins, each one of them.
I'm close to RDA on these now and supplement only a few to support methylation, I always had strong reactions to vitamins. Minerals change my tolerance, especially thyroid related.

I came to the same conclusions that norms are one thing and what we need is another. I can tolerate 4mg of elemental copper well, my ratio is about 4:1 zinc to copper. I haven't tried germanium and strontium yet, what is your experience with them?

I would love to do it without tedious accounting. But I can't see a way, other than spreadsheets, to supplement comprehensively not in a haphazard way and possibly dangerous way. Only documenting and comparing with lab results, does allow finding correlations afterward.

I wonder how many people do that. I kind of like it, it keeps my brain stimulated. I make so many changes that it would be impossible to remember it anyways. It's a lot of good data for analysis.
 

pamojja

Senior Member
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2,782
Location
Austria
definitely less magnesium. Is that 2g by the way, how is that even possible.

Thanks for answering, always good to learn from others with different situation. Most of the 1.9 g of Mg is from the mineral water, with 1g/l. I do have loose stools, but mainly in the morning. Guess with night's sleep transit time, along with it during the largest part of the day, at least some should get absorbed.

My Mg deficiency with very painful muscle cramps only started with sufficient vitamin D. Guess I've been subclinical deficient, and by higher utilization from D, it must have pushed me into severe deficiency. Even with such high oral doses, it alleviated the cramps only somewhat.

Finally, only 32 Mg-sulfate IVs by my GP ceased the muscle cramps almost completely. Therefore, I still keep the oral Mg intake high.

I haven't tried germanium and strontium yet, what is your experience with them?

Generally, I don't feel individual supplements (except what's described further up this thread), especially those with relatively low doses. Though I do suspect germanium to have kept my blood pH alkaline, the initial years.
 

Viala

Senior Member
Messages
853
My Mg deficiency with very painful muscle cramps only started with sufficient vitamin D.

Thanks likewise.
Muscle cramps explain high magnesium tolerance. Interesting, since I took too much vitamin D a while ago. It doesn't work on me now.

Generally, I don't feel individual supplements (except what's described further up this thread), especially those with relatively low doses.

I can feel the difference with practically every supplement. I don't know if that's good or not.
 
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