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Does taking more B12 make you need more folate?

Messages
87
I know B12 is water soluble so you will just pee out anything you don't absorb, but if you took someone that was on a lower maintenance dose of B12 and fully saturated them via regular injection... Would that person's need for folate or utilization of folate actually go up or down?
 

drmullin30

Senior Member
Messages
218
Hi Blue, my experience has been that increases in B12 dosage need to be matched with an increase in folate otherwise I get folate deficiency symptoms.
 
Messages
87
Hi Blue, my experience has been that increases in B12 dosage need to be matched with an increase in folate otherwise I get folate deficiency symptoms.

I am finding that as well I just wasn't sure if B12 absorption peaked and then folate could be backfilled from there