Does taking more B12 make you need more folate?

[Bluelude1]

I know B12 is water soluble so you will just pee out anything you don't absorb, but if you took someone that was on a lower maintenance dose of B12 and fully saturated them via regular injection... Would that person's need for folate or utilization of folate actually go up or down?

 

[drmullin30]

Hi Blue, my experience has been that increases in B12 dosage need to be matched with an increase in folate otherwise I get folate deficiency symptoms.

 

[Bluelude1]

Hi Blue, my experience has been that increases in B12 dosage need to be matched with an increase in folate otherwise I get folate deficiency symptoms.

I am finding that as well I just wasn't sure if B12 absorption peaked and then folate could be backfilled from there