@lnester7 I started on 2 RNA formulas approx March 2013, later added a couple more. I adjust all my supp dosages by self-testing. Initially I was using all 4 daily, the CBS w/ each meal. As time went on, I no longer tested + for the bowel or leaky gut. I now use 2 drops MAO and CBS about once/week. However, I always self-test for more when I'm in the midst of detox, occasionally to add the other two as well. I Interpret this as efficacy and progress. I can't comment specifically on remission of symptoms or other signs. I'm involved simultaneously in methylation, low dose naltrexone, uncovering and treating for mast cell and adrenal issues, and using malic acid for ammonia. All these things also impact. The fact that my body still tests+ for these in low doses from time to time convinces me that they're effective.