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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Yeah, but that terminology...doesn't that makes it sound like we have a choice and just are not preferring to make the effort? I just hate that word "preference" used there.is effort preference based
23.5% recovery rate, decent numbers indeed... (sarcasm)Within four years of participation, four of the 17 PI-ME/CFS participants had a spontaneous full recovery.
We can't "push through" our fatigue-like state because the part of the brain responsible for the ability to "push through" isn't working properly.
This is who wrote it. This guy is the lead author. Now everything is clear.
Except we can? And we get worse from it? That's completely different from some brain dysfunction making it so you always have a preference to not push through. What you're saying is literally contrary to the clinical picture of the disease and all the experimental data, including the ones from this study.I read it as meaning that the part of our brain that creates our willingness to exert ourselves is malfunctioning due to a biological mechanism. I expect psychologists will interpret it differently. We can't "push through" our fatigue-like state because the part of the brain responsible for the ability to "push through" isn't working properly.
And then they have to learn over sometimes quite a long period of time to stop doing that.
But the method of the actual paper says its not required. On top of that they never tested for PEM, they did a single day of CPET but not both days so they couldn't quantify and confirm PEM so its just a self report in the supplement information. This is the second paper I have seen that said PEM wasn't in the selection criteria and yet magically by the conclusion they totally pinky swear did account for it despite having written nothing about it and ignored it completely throughout the paper.So Brian Walitt says PEM was indeed required for the study...and kind of off-topic but @Tsukareta - Febreeze is the devil's work...that stuff is horrible...
And we already had a recent study about LC focusing on serotonin so that plus this, esp that top paragraph, still sounds like "future intervention" is still going to be the same old misguided interventions of SSRIs and SNRIs (or something similar)Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical conditioning.
Immune profiling suggested chronic antigenic stimulation with increase in naïve and decrease in switched memory B-cells. Alterations in gene expression profiles of peripheral blood mononuclear cells and metabolic pathways were consistent with cellular phenotypic studies and demonstrated differences according to sex. Together these clinical abnormalities and biomarker differences provide unique insight into the underlying pathophysiology of PI-ME/CFS, which may guide future intervention.