I believe some of this is semantics. The CD8+ marker is for Cytotoxic. I believe the CD57+ is often used as a marker for NKT cells (which can be CD8+ cytotoxic T-cells).
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I have to laugh when these studies say there are no specific biological markers in cfsme. They only been researching and finding low nk function in cfsme patients at griffith university australia since about 2009.
Dr Nancy Klimas has found low nk function in cfsers since the mid 80s.
Really! This is something they should be chasing down the dam rabitt hole. Stands out like dog nuggets and could easily be responsible for the onset of cfsme but also could make cfsme a chronic illness as we no longer have a healthy immune system to suppress viruses that normal people can.
The only genuine immune drug helpful for cfs, ampligen, not only improved ohysical symptoms like general wellbeing, aerobic capacity and suprise suprise, it increased NK function.
See said the blind man.
Slightly different subject, but are they testing the nk function of the covid long hallers?
Not every patient has low NK function (i don't for example, even though i have extremely low CD8+CD57+ cells). If i remember correctly from the studies it's about 70% of patients. So unfortunately it is not a marker for ME/CFS
I would call it dysautonomia since it is due to a dysfunction of the autonomic nervous system. But yes, prolonged activation of the sympathetic nervous system, whether due to chronic stress or dysautonomia, can suppress the immune system.
Australian researchers printed this or just told us who were in the study at the time but they also found a significant number of cfsers had low cd8 t cell function.
This wouldn't be a stretch because a while ago i tested CD40L, which is mainly expressed on activated T cells, and it was 3 times over the upper limit. So it seems that CD8+CD57+ identifies a subset of activated T cells that have "grown old" but doesn't necessarily mean that if you have activated T cells in general you end up with a high CD8+CD57+ number.
I have emailed a few people involved in studies with these cells and according to them another possible explanation for a low CD8+CD57+ number could be an overactive immune system.
Which researcher was that? Maybe I can find their publication...
Now if you find a way to increase cd8 T cells,
We need an app that would allow us to vary any factor in our bodies. cd8 cells? Just move the indicator up a bit.
Of course, by the time we reach that level of technology, we probably won't have biological bodies anymore.