I would spend some time here using the google search feature and research NAC and 5HTP and any reactions to them. (When you click on the search box there is this line of small text below the input box. Click the link to search: "You can also try a
Google Site Search")
With any luck, you'll find some discussion that reference snps that you have -- how those supps interact with specific defects in the methylation cycle. Even if you do, you won't know how you might react to those supps till you try them. As long as no one is reporting major, sustained setbacks from trying them, it's probably worth a shot to try them.
I'd advise spending some time reading Heartfixer's page.
http://www.heartfixer.com/AMRI-Nutrigenomics.htm and also Ben Lynch's mthfrsupport.com. The more you know about methylation and the current professional thinking about it the better you can evaluate your naturopath's grasp of it.
Ultimately, you have to decide for yourself what path is likely to benefit you most. As Sherpa referenced, lots of frustration with docs and naturopaths here, with good reason.
Other folks have had great results seeing top notch CFS/ME specialists.
And there are CFS recovery stories out there of people who returned to normal activity levels after simply long periods of rest and learning how to break exertion into smaller tasks and intersperse with restorative time. Those people may not have had full blown ME or may have caught it early but it's a viable alternative to consider as well. Google CFS recovery stories and spend some time reading those, so you get an idea of what helps people, how many people report succeeding with it and what "recovery" looks like, when it happens.
I stopped seeing my naturopath a year and a half ago because I didn't feel like I was making any further improvement and had unexpectedly crashed. I then saw an integrative medicine specialist who ordered some useful tests but had insufficient advice about how to address the issues that were uncovered. When I got health insurance coverage, I saw a Kaiser physician who was worse than useless, then a slightly better one who was still essentially useless.
I am now seeing a different cash-basis holistic physician close to home who has some familiarity with methylation but feels that healing the gut is the most important thing to do and that supporting methylation is helpful but not the key fix. The best thing he is doing for me is prescribing b12 shots and helping me deal with low potassium symptoms.
He doesn't buy a high-dose methylfolate protocol and I don't blame him -- I don't expect him to read here and absorbs Freddd's voluminous posts and the testimonials of various members who are doing better on it.
You could ask your doctor where she learned/formulated her methylation protocol. If you are not certain that methylation defects are a foundational problem for you, you could continue to follow your naturopath's protocol for a while, but if she is not deeply familiar with chronic fatigue/ME or methylation, I can't see why you would want to, particularly if you feel like you are getting worse or are significantly impacted now by the dysfunction.
I find myself feeling my way through this now, not blindly following anyone's professional or anectdotal advice. Journaling helps me keep track of factors that may be positively or negatively influencing my health. There are ways to access deeper knowing, if you feel that would be valid or useful for you to try. Some people use applied kinesiology, I've been getting a lot out of dream work lately.
No easy answers, as far as I can tell. But a lot of chances to improve your connection with your body and choose healthier ways to live and reframe *everything* about your life, your health and your self.
good luck!
Sue
