jimells
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From 1997...
https://www.researchgate.net/publication/14131133
I keep digging through the headline hype with my manure fork trying to find the pony, but so far it seems the study only tells us what we already knew. How can it be that 20 years later we *still* don't know the source of the TGF? Why has no one tried to answer this obvious question?
The new study doesn't even mention the "200-fold more active" observation, or even reference the 1997 study. Is this a red herring? I am particularly intrigued by this because the 1997 study lists Komaroff as a co-author, and he reviewed the new study.
Two decades of torturing cytokine data has resulted in NO treatments, treatment targets, or management strategies. Time to move on?
https://www.researchgate.net/publication/14131133
Elevation of Bioactive Transforming Growth Factor-beta in Serum from Patients with Chronic Fatigue Syndrome
ADRIENNE L. BENNETT, CHUN C. CHAO, SHUXIAN HU, DEDRA BUCHWALD, LAURA R. FAGIOLI, PETER H. SCHUR, PHILLIP K. PETERSON, and ANTHONY L. KOMAROFF
The current finding that TGF-beta is significantly elevated among patients with CFS supports the
findings of two previous studies examining smaller numbers of CFS patients.
In conclusion, TGF-beta levels were significantly higher in CFS patients compared to patients with various diseases known to be associated with immunologic abnormalities and/or pathologic fatigue.
These findings raise interesting questions about the possible role of TGF in the pathogenesis of CFS.
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TGF-beta has been found to be expressed constitutively in a variety of cells, including
platelets, macrophages, neutrophils, and lymphocytes. Almost all of the TGF-beta produced by these cells is released in a latent high molecular weight complex form.
The bioactive form of TGF-beta, which was measured in the present study, is 200-fold more active than the latent form. The cellular source(s) of TGF-beta in the serum and the physiologic mechanisms of its activation are presently unknown.
I keep digging through the headline hype with my manure fork trying to find the pony, but so far it seems the study only tells us what we already knew. How can it be that 20 years later we *still* don't know the source of the TGF? Why has no one tried to answer this obvious question?
The new study doesn't even mention the "200-fold more active" observation, or even reference the 1997 study. Is this a red herring? I am particularly intrigued by this because the 1997 study lists Komaroff as a co-author, and he reviewed the new study.
Two decades of torturing cytokine data has resulted in NO treatments, treatment targets, or management strategies. Time to move on?