Marco
Grrrrrrr!
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...but there is an interesting parallel to be drawn between the results of this cross-sectional study and the (initial, unpublished) results coming from the longitudinal study currently underway at the Younger Lab. They too are finding a correlation between certain cytokines and severity of symptoms, and again finding that whilst this correlation exists the actual cytokine levels on average are within normal tolerances. This seems consistent to me and if the case would indicate that cytokines drive the disease but it would appear that there is some kind of abnormal response to these cytokines or that the cytokines are correlated with another disease process that is doing the actual damage..
Exactly. 'Within normal parameters' suggests the problem may lie with signalling/receptors or some other immune signal associated with 'inflammation'.