I suppose it could be cured if that dysfunction itself is at the core of the disease. There are unfortunately some other possibilities as well. For example, the hypotheses from Naviaux and Prusty propose that ME/CFS is caused by a switch of state of mitochondria. In short, they believe that in the presence of a virus or some other factor that could be the ME/CFS plasma, the mitochondria go into a protective, antiviral mode, which then come at the cost of cellular energy.
Now these mitochondria could presumably rather quickly go back into their normal state and you would gain the energy back. There is also not necessarily much "disease process" going on in the sense that there would be any detectable permanent damage from all this, other than the energy dysregulation.
Assuming this hypothesis, it could be possible to temporarily reverse the signal that is causing the mitochondrial dysregulation, let's say through some brain hacking, and regain the energy. The problem is that if the underlying pathology remains and is not dealt with, you would most likely end up back in the old state sooner or later, a bit like if you apply a force to a pendulum you get it moving, only for it to return back to the same position later.
I guess what I'm saying is that if there is an underlying cause and dysfunctioning pathways are an adaptation to this, you would never really escape from ME/CFS state permanently. I have had success in temporarily reducing my ANS symptoms for example with lots of different methods including some drugs, supplements, alcohol, relaxation methods, vagus nerve stimulation etc., but the old state always returns.
