slysaint
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Wonder if any of the MEGA team will have followed this conference?She's not kidding. Makes the UK look mediaeval.
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Coverage from IACFS/ME Florida conference, 27-30 Oct 2016
- Thread starter Sasha
- Start date
I thought of an alternative mechanism to autoimmune ... if the cells that produce antibodies also produce some sort of signal that tells mitochondria to go into a survival state ( this one would be more in fitting with the dauer state theory ), I have no idea whether this reflects how these things function in reality though.
Either way I think we need to be looking at the cells which Rituximab targets and trying to find ways that they could possibly affect the metabolism of the body in general, while at the same time finish the 'big data' study to rule out other possible explanations.
Either way I think we need to be looking at the cells which Rituximab targets and trying to find ways that they could possibly affect the metabolism of the body in general, while at the same time finish the 'big data' study to rule out other possible explanations.
Marky90
Science breeds knowledge, opinion breeds ignorance
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Marky90
Science breeds knowledge, opinion breeds ignorance
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Marky90
Science breeds knowledge, opinion breeds ignorance
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aimossy
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Cort's tweets re exercise testing findings from Norwegian group ( compiled) :
"#IACFS/ME #ME/CFS: - Norwegian researchers use 2-day exercise test - inserted arteriol catheter - found lower peak VO2 day 1 or 2 but
# non-significant change in peak V02 from day1to 2; ie. no drop in peak Vo2 from day 1 to 2
# ME/CFS patients had much higher lactate levels BOTH days and lactate accumulates earlier in ME/CFS
# suggests disrupted energy metabolism similar to suggested by Fluge and Mella.lactate change called "left shift in lactate
# "left shift in lactate curve" - lactate accumulation is INCREASED during second test - same found in overtrained athletes
# Lactate accumulation in the healthy controls, by the way, DECREASED on the second exercise test"
"#IACFS/ME #ME/CFS: - Norwegian researchers use 2-day exercise test - inserted arteriol catheter - found lower peak VO2 day 1 or 2 but
# non-significant change in peak V02 from day1to 2; ie. no drop in peak Vo2 from day 1 to 2
# ME/CFS patients had much higher lactate levels BOTH days and lactate accumulates earlier in ME/CFS
# suggests disrupted energy metabolism similar to suggested by Fluge and Mella.lactate change called "left shift in lactate
# "left shift in lactate curve" - lactate accumulation is INCREASED during second test - same found in overtrained athletes
# Lactate accumulation in the healthy controls, by the way, DECREASED on the second exercise test"
aimossy
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Cort's tweets re Keller exercise testing findings (compiled):
"#IACFS/ME #ME/CFS: Keller - Subsets in exercise testing during 2-day exercise test - reduced VO2 max found in 4 studies w/about 100 patients
# Keller sees problems with VO2 max, VO2 anaerobic threshold, chronotropic incompetence, ventilation, blood pressure
# Keller - suggests that even patients who can produce VO2 max results are not suitable for graded exercise therapy
# - identical twins, one twin gets ill after flu - was the more physically active twin- was runner and cyclist
# c -reactive protein soars during two day exercise test - but CPET exercise results NORMAL - there's more to exercise
# than CPET study shows, ll twin also shows gut problems after exercise- have to look further to understand exercise issues"
"#IACFS/ME #ME/CFS: Keller - Subsets in exercise testing during 2-day exercise test - reduced VO2 max found in 4 studies w/about 100 patients
# Keller sees problems with VO2 max, VO2 anaerobic threshold, chronotropic incompetence, ventilation, blood pressure
# Keller - suggests that even patients who can produce VO2 max results are not suitable for graded exercise therapy
# - identical twins, one twin gets ill after flu - was the more physically active twin- was runner and cyclist
# c -reactive protein soars during two day exercise test - but CPET exercise results NORMAL - there's more to exercise
# than CPET study shows, ll twin also shows gut problems after exercise- have to look further to understand exercise issues"
That's worrying.
aimossy
Senior Member
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@Marky90 Sorry I compiled them up to help my brain.
What's up with the different VO2 max findings between groups I wonder? It could be explainable. I hope these Lactate findings from Norwegians can be repeated.
Edit: Um, I think Ungers group found same as Keller group?
What's up with the different VO2 max findings between groups I wonder? It could be explainable. I hope these Lactate findings from Norwegians can be repeated.
Edit: Um, I think Ungers group found same as Keller group?
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Isn't Unger/CDC only doing a one day CPET?
It's very worrying that the Van Ness / Keller two day CPET VO2 max findings were not confirmed by the Norwegians. Another 'diagnostic marker' bites the dust?
It will be interesting to see what the NIH / Nath study shows re: CPET.
I don't understand how this disease was ever considered to be psychological when it seems it is easy to find objective physical differences with seemingly a new finding at least once a month on average now.
You dont even need scientific measuring equipment, I used to be able to press 14 buttons per second on a keyboard and mouse in order, but my joints are suddenly now in such bad condition that you can see obvious physical alteration on my toes
You dont even need scientific measuring equipment, I used to be able to press 14 buttons per second on a keyboard and mouse in order, but my joints are suddenly now in such bad condition that you can see obvious physical alteration on my toes
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Is anyone compiling the PR tweets? #IACFSMEConf
It might be interesting to put the PR tweets and Cort's side-by-side in case they have different/supplemental info.
It might be interesting to put the PR tweets and Cort's side-by-side in case they have different/supplemental info.
Very interesting:
Truncal Ataxia is an Unrecognized Cause of Postural Intolerance in Patients with Myalgic Encephalomyelitis
Kunihisa Miwa, MD
Objectives. Most patients with myalgic encephalomyelitis (ME) have orthostatic intolerance (OI) which is the primary factor restricting the daily functional capacity. OI is characterized by the inability to remain upright without severe signs and symptoms, such as hypotension, palpitation, pallor, fatigue and nausea. Most symptoms of OI have been surmised to be related to reduced cerebral blood flow and the compensatory sympathetic activation. Indeed, many patients have postural orthostatic tachycardia, orthostatic hypotension, neurally mediated hypotension and low cardiac output with a small left ventricle. With further progression of the disease, patients may have even sitting intolerance and finally become bedridden. Static balance is an essential element for the performance of postural stability. The possible role of disequilibrium in the genesis of both orthostatic and sitting intolerance was examined in the patients.
Methods. The study subjects comprising 35 patients with ME (8 men and 27 women, mean age: 36±10 years) underwent both the conventional 10-min standing and sitting tests separately and also neurological examinations including Romberg test.
Results. The patients were divided into 10 with a positive Romberg test (Group P) and 25 with a negative Romberg test (Group N). Postural sway was observed during the standing test in all (100%, p<0.01) of Group P in contrast to 5 (20%) of Group N. None of Group P was able to stand on one-leg or had normal tandem gait. All of Group P complained of symptoms during both the standing and sitting tests in which many of them (40%) were not able to complete the 10-min standing, and some (20%) not even 10-min sitting. In contrast, all Group N patients were able to stand on one-leg and demonstrated smooth tandem gait. All of them were able to complete both tests. As compared with Group N (performance status scores: 3-6), Group P had significantly (p<0.01) higher performance status scores (5-8), suggesting severe restriction of the activities of daily living.
Conclusions: Patients with ME and a positive Romberg test complaints of not only OI but also sitting intolerance. Truncal ataxia or disequilibrium appears to play an important role in the genesis of the postural intolerance and can be considered a useful sign for advanced disease.
Truncal Ataxia is an Unrecognized Cause of Postural Intolerance in Patients with Myalgic Encephalomyelitis
Kunihisa Miwa, MD
Objectives. Most patients with myalgic encephalomyelitis (ME) have orthostatic intolerance (OI) which is the primary factor restricting the daily functional capacity. OI is characterized by the inability to remain upright without severe signs and symptoms, such as hypotension, palpitation, pallor, fatigue and nausea. Most symptoms of OI have been surmised to be related to reduced cerebral blood flow and the compensatory sympathetic activation. Indeed, many patients have postural orthostatic tachycardia, orthostatic hypotension, neurally mediated hypotension and low cardiac output with a small left ventricle. With further progression of the disease, patients may have even sitting intolerance and finally become bedridden. Static balance is an essential element for the performance of postural stability. The possible role of disequilibrium in the genesis of both orthostatic and sitting intolerance was examined in the patients.
Methods. The study subjects comprising 35 patients with ME (8 men and 27 women, mean age: 36±10 years) underwent both the conventional 10-min standing and sitting tests separately and also neurological examinations including Romberg test.
Results. The patients were divided into 10 with a positive Romberg test (Group P) and 25 with a negative Romberg test (Group N). Postural sway was observed during the standing test in all (100%, p<0.01) of Group P in contrast to 5 (20%) of Group N. None of Group P was able to stand on one-leg or had normal tandem gait. All of Group P complained of symptoms during both the standing and sitting tests in which many of them (40%) were not able to complete the 10-min standing, and some (20%) not even 10-min sitting. In contrast, all Group N patients were able to stand on one-leg and demonstrated smooth tandem gait. All of them were able to complete both tests. As compared with Group N (performance status scores: 3-6), Group P had significantly (p<0.01) higher performance status scores (5-8), suggesting severe restriction of the activities of daily living.
Conclusions: Patients with ME and a positive Romberg test complaints of not only OI but also sitting intolerance. Truncal ataxia or disequilibrium appears to play an important role in the genesis of the postural intolerance and can be considered a useful sign for advanced disease.
Cardiopulmonary Exercise Testing Demonstrates Post-Exertional Chronotropic Incompetence
Bettencourt, Haylee1; Davenport, Todd E.2;Stevens, Jared3; Stevens, Staci R.3; Snell, Christopher R.3 and Van Ness, J. Mark1
1. Department of Health, Exercise, and Sport Science, University of the Pacific, Stockton, CA, United States.2. Department of Physical Therapy, University of the Pacific, Stockton, CA, United States. 3. Workwell Foundation, Ripon, CA, United States.
Background : Chronotropic incompetence (CI) is the inability of the heart to increase its rate commensurate with increased functional demands. CI is common in patients with cardiovascular disease, and associated with exercise intolerance that impairs quality of life. In previous studies we’ve demonstrated that patients with CFS/ME experience post-exertional exercise intolerance.
Objective: This study examined the heart rate response to exercise to determine whether CI is associated with post-exertional exercise intolerance.
Methods: 39 females with CFS/ME and 39 age- and weight-matched control subjects (CON). Subjects performed a graded exercise test to volitional fatigue on a cycle ergometer (Test 1). A subset of 17 subjects with CFS/ME and 18 CON subjects repeated a second exercise test 24 hours later to examine the exercise heart rate response in the post-exertional state (Test 2). Heart rate (HR) was collected continuously throughout the exercise test. Data were analyzed for resting (Rest), at anaerobic threshold (AT), and at peak exercise (Peak). Only subjects that reached criteria for maximal effort were included in the analysis. Repeated measures ANOVA was used to compare HR measurements between groups and tests.
Results : HR in the CON group was not significantly different between Test 1 and 2 at
any exercise intensity (Rest: 88±11 vs 89±19; AT: 126±17 vs 121±12; and Peak: 182±12 vs 180±15; values expressed as mean ± standard deviation). The CFS/ME group responses were not significantly different from CON on Test 1 (rest: 90±15; AT: 120±13; Peak: 170±10). However, the CFS/ME group demonstrated significantly lower Peak heart rate values on Test 2 (Rest: 100±18; AT: 116±10; Peak: 165±10; p<.05) compared to Test 1. HR measurements were not significantly different between groups or exercise tests for any group except the diminished peak value during the second exercise test in subjects with CFS/ME group.
Conclusion : Patients with CFS/ME appear to display post- exertional reductions in the peak HR response to exercise, which could contribute to exercise intolerance and observed reductions in oxygen consumption during post-exertional malaise. The combination of elevation in resting heart rate and reduction in peak exercise heart rate may contribute to the impaired quality of life.
Bettencourt, Haylee1; Davenport, Todd E.2;Stevens, Jared3; Stevens, Staci R.3; Snell, Christopher R.3 and Van Ness, J. Mark1
1. Department of Health, Exercise, and Sport Science, University of the Pacific, Stockton, CA, United States.2. Department of Physical Therapy, University of the Pacific, Stockton, CA, United States. 3. Workwell Foundation, Ripon, CA, United States.
Background : Chronotropic incompetence (CI) is the inability of the heart to increase its rate commensurate with increased functional demands. CI is common in patients with cardiovascular disease, and associated with exercise intolerance that impairs quality of life. In previous studies we’ve demonstrated that patients with CFS/ME experience post-exertional exercise intolerance.
Objective: This study examined the heart rate response to exercise to determine whether CI is associated with post-exertional exercise intolerance.
Methods: 39 females with CFS/ME and 39 age- and weight-matched control subjects (CON). Subjects performed a graded exercise test to volitional fatigue on a cycle ergometer (Test 1). A subset of 17 subjects with CFS/ME and 18 CON subjects repeated a second exercise test 24 hours later to examine the exercise heart rate response in the post-exertional state (Test 2). Heart rate (HR) was collected continuously throughout the exercise test. Data were analyzed for resting (Rest), at anaerobic threshold (AT), and at peak exercise (Peak). Only subjects that reached criteria for maximal effort were included in the analysis. Repeated measures ANOVA was used to compare HR measurements between groups and tests.
Results : HR in the CON group was not significantly different between Test 1 and 2 at
any exercise intensity (Rest: 88±11 vs 89±19; AT: 126±17 vs 121±12; and Peak: 182±12 vs 180±15; values expressed as mean ± standard deviation). The CFS/ME group responses were not significantly different from CON on Test 1 (rest: 90±15; AT: 120±13; Peak: 170±10). However, the CFS/ME group demonstrated significantly lower Peak heart rate values on Test 2 (Rest: 100±18; AT: 116±10; Peak: 165±10; p<.05) compared to Test 1. HR measurements were not significantly different between groups or exercise tests for any group except the diminished peak value during the second exercise test in subjects with CFS/ME group.
Conclusion : Patients with CFS/ME appear to display post- exertional reductions in the peak HR response to exercise, which could contribute to exercise intolerance and observed reductions in oxygen consumption during post-exertional malaise. The combination of elevation in resting heart rate and reduction in peak exercise heart rate may contribute to the impaired quality of life.
aimossy
Senior Member
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Here is the Unger/CDC VO2 paper abstract and they also looked at Lactate. I think my heads going to explode regarding varying findings soon....
"Exercise testing data from the Multi-Site Clinic Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
(MCAM) Study Dane B. Cook1,3, Jin-Mann S. Lin2, Elizabeth R. Unger2 Ryan Dougherty1,3, Stephanie Van Riper1,3 and MCACM Workgroup 1 William S. Middleton Memorial Veterans Hospital, Madison WI, 2Centers for Disease Control and Prevention, Atlanta GA, 3University of Wisconsin-Madison, Madison WI
Background: Exercise testing has proven useful for both determining aerobic fitness and as a physical stressor in ME/CFS. Objective: To describe preliminary cardiopulmonary exercise testing data from the MCAM Study. Methods: Maximal exercise testing was performed in six clinics using a ramped protocol on a cycle ergometer. Exercise began with a one-minute warm-up. Thereafter, exercise intensity increased at a rate of 15-Watts/min until volitional exhaustion. Oxygen consumption (VO2), carbon dioxide production, ventilation (VE), heart rate (HR) and perceived exertion (RPE) were directly measured using a metabolic cart, HR monitor and RPE scale, respectively. Lactate was measured from blood (finger stick) at baseline, minute-2, peak exercise and minutes 3, 6 and 10 during recovery. Metabolic and perceptual data were independently and blindly assessed to determine peak effort criteria, anaerobic threshold, lactate and perceived exertion responses during exercise. Following blind assessment, data were coded for gender and illness category. Peak exercise effort was determined using American College of Sports Medicine (ACSM) criteria and relaxed criteria for respiratory exchange ratio (RER=1.1) and HR (85%_age-predicted max) Anaerobic threshold was determined using the Vslope method.
Results: One-hundred and eighty tests were evaluated including 135 (39 male) ME/CFS patients and 45 (18 male) controls. ME/CFS patients were significantly older (ME/CFS: 50.2±13 yrs; control: 42.5±14.5 yrs, p<0.05), heavier (ME/CFS: 173.5±41.2 lbs; control: 152.9±33.3 lbs, p<0.05) and had higher BMIs (ME/CFS: 27.3±5.8; control: 24.6±4.5, p<0.05). Over 80% of the sample achieved peak exercise effort using ACSM criteria. When the criteria were relaxed, 92% of the sample met criteria. Percentages of achieving peak effort were similar for ME/CFS and controls for both ACSM (ME/CFS 81%; control: 78%) and relaxed (ME/CFS: 89%; control: 93%) criteria. Controlling for age and BMI, ME/CFS patients had significantly (p<0.05) lower peak VO2, VE, Watts, HR and lactate, but significantly (p<0.05) higher RER and RPE. Anaerobic threshold occurred at similar percentages of peak VO2 (ME/CFS: 54%; control: 53%) and peak Watts (ME/CFS: 39%; control: 45%).
Conclusions: These preliminary data demonstrate the validity of the exercise testing procedures for the multi-site study. Future work will include exercise efficiency assessments and relationships to symptoms and cognitive function."
"Exercise testing data from the Multi-Site Clinic Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
(MCAM) Study Dane B. Cook1,3, Jin-Mann S. Lin2, Elizabeth R. Unger2 Ryan Dougherty1,3, Stephanie Van Riper1,3 and MCACM Workgroup 1 William S. Middleton Memorial Veterans Hospital, Madison WI, 2Centers for Disease Control and Prevention, Atlanta GA, 3University of Wisconsin-Madison, Madison WI
Background: Exercise testing has proven useful for both determining aerobic fitness and as a physical stressor in ME/CFS. Objective: To describe preliminary cardiopulmonary exercise testing data from the MCAM Study. Methods: Maximal exercise testing was performed in six clinics using a ramped protocol on a cycle ergometer. Exercise began with a one-minute warm-up. Thereafter, exercise intensity increased at a rate of 15-Watts/min until volitional exhaustion. Oxygen consumption (VO2), carbon dioxide production, ventilation (VE), heart rate (HR) and perceived exertion (RPE) were directly measured using a metabolic cart, HR monitor and RPE scale, respectively. Lactate was measured from blood (finger stick) at baseline, minute-2, peak exercise and minutes 3, 6 and 10 during recovery. Metabolic and perceptual data were independently and blindly assessed to determine peak effort criteria, anaerobic threshold, lactate and perceived exertion responses during exercise. Following blind assessment, data were coded for gender and illness category. Peak exercise effort was determined using American College of Sports Medicine (ACSM) criteria and relaxed criteria for respiratory exchange ratio (RER=1.1) and HR (85%_age-predicted max) Anaerobic threshold was determined using the Vslope method.
Results: One-hundred and eighty tests were evaluated including 135 (39 male) ME/CFS patients and 45 (18 male) controls. ME/CFS patients were significantly older (ME/CFS: 50.2±13 yrs; control: 42.5±14.5 yrs, p<0.05), heavier (ME/CFS: 173.5±41.2 lbs; control: 152.9±33.3 lbs, p<0.05) and had higher BMIs (ME/CFS: 27.3±5.8; control: 24.6±4.5, p<0.05). Over 80% of the sample achieved peak exercise effort using ACSM criteria. When the criteria were relaxed, 92% of the sample met criteria. Percentages of achieving peak effort were similar for ME/CFS and controls for both ACSM (ME/CFS 81%; control: 78%) and relaxed (ME/CFS: 89%; control: 93%) criteria. Controlling for age and BMI, ME/CFS patients had significantly (p<0.05) lower peak VO2, VE, Watts, HR and lactate, but significantly (p<0.05) higher RER and RPE. Anaerobic threshold occurred at similar percentages of peak VO2 (ME/CFS: 54%; control: 53%) and peak Watts (ME/CFS: 39%; control: 45%).
Conclusions: These preliminary data demonstrate the validity of the exercise testing procedures for the multi-site study. Future work will include exercise efficiency assessments and relationships to symptoms and cognitive function."
Blood lactate increases more rapidly after a previous exercise challenge in patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) than in healthy subjects
Lien K, Johansen B, Veierød MB, Haslestad AS, Melsom MN, Kardel KR, Iversen PO
Background: Previous findings from repeated cardiopulmonary exercise testing (CPET) suggest that exercise on day 1 negatively influences peak oxygen uptake (peak VO2) on day 2 in patients with CFS/ME. Accumulation of lactate denotes a transition to anaerobic glycolysis, a limiting factor on maximal performance.
Objectives: The main aim was to examine the effect of an exercise challenge on peak VO2 and lactate accumulation in CFS/ME patients performing CPET on two consecutive days.
Methods: Eighteen female patients (18-50 years) fulfilling the Canadian Consensus Criteria and the International Consensus Criteria for CFS/ME and 15 controls (healthy, sedentary women; 18-50 years) performed two CPET 24 hours apart. We measured oxygen uptake and collected arterial blood samples for lactate analysis at baseline and every 30th second during the tests. Two-sample and paired t-tests and mixed model analysis for repeated measurements were applied.
Results: Lactate levels per work rate were higher in patients than in controls on both test days (pinteraction<0.001). Furthermore, lactate accumulation on test 2 occurred earlier in the patients, and later in healthy subjects, compared to their respective lactate accumulation on test 1 (pinteraction<0.001). At test 1, mean (SD) peak VO2 (ml/kg/min) was lower in patients than in the controls (24.2 (4.9) vs. 36.6 (6.2), p<0.001). Mean difference in test- retest peak VO2 was -1.4 (1.1) among the patients (p<0.001), whereas no change was found in the controls (-0.9 (1.8) p=0.07). However, the mean test-retest difference in peak VO2 did not differ between the groups (p=0.33).
Conclusion: CFS/ME patients have a higher lactate level than heathy subjects at baseline and per work rate on both tests. In addition, the first exercise test seems to induce an earlier lactate accumulation in patients, when retested the next day. This is not the case in healthy subjects. Furthermore, this study confirms that CFS/ME patients have a decreased physical capacity compared to healthy subjects, but the change in peak VO2 after repeated CPET did not discriminate between patients and healthy controls.
Author information: Katarina Lien, MD, PhD research fellow at the Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway. Attending physician at the CFS/ME Centre, Department of Medicine, Oslo University Hospital, NorwayMailing address: Katarina Lien, Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 1046 Blindern, 0317 Oslo, Norway.E-mail address: katarina.lien@medisin.uio.noFunding: This project has been made possible by a research grant from the Norwegian
ExtraFoundation for Health and Rehabilitation. The grant proposal was submitted through the
CFS/ME patient organization MENiN – The ME Network in NorwayConflict of interest: None
Lien K, Johansen B, Veierød MB, Haslestad AS, Melsom MN, Kardel KR, Iversen PO
Background: Previous findings from repeated cardiopulmonary exercise testing (CPET) suggest that exercise on day 1 negatively influences peak oxygen uptake (peak VO2) on day 2 in patients with CFS/ME. Accumulation of lactate denotes a transition to anaerobic glycolysis, a limiting factor on maximal performance.
Objectives: The main aim was to examine the effect of an exercise challenge on peak VO2 and lactate accumulation in CFS/ME patients performing CPET on two consecutive days.
Methods: Eighteen female patients (18-50 years) fulfilling the Canadian Consensus Criteria and the International Consensus Criteria for CFS/ME and 15 controls (healthy, sedentary women; 18-50 years) performed two CPET 24 hours apart. We measured oxygen uptake and collected arterial blood samples for lactate analysis at baseline and every 30th second during the tests. Two-sample and paired t-tests and mixed model analysis for repeated measurements were applied.
Results: Lactate levels per work rate were higher in patients than in controls on both test days (pinteraction<0.001). Furthermore, lactate accumulation on test 2 occurred earlier in the patients, and later in healthy subjects, compared to their respective lactate accumulation on test 1 (pinteraction<0.001). At test 1, mean (SD) peak VO2 (ml/kg/min) was lower in patients than in the controls (24.2 (4.9) vs. 36.6 (6.2), p<0.001). Mean difference in test- retest peak VO2 was -1.4 (1.1) among the patients (p<0.001), whereas no change was found in the controls (-0.9 (1.8) p=0.07). However, the mean test-retest difference in peak VO2 did not differ between the groups (p=0.33).
Conclusion: CFS/ME patients have a higher lactate level than heathy subjects at baseline and per work rate on both tests. In addition, the first exercise test seems to induce an earlier lactate accumulation in patients, when retested the next day. This is not the case in healthy subjects. Furthermore, this study confirms that CFS/ME patients have a decreased physical capacity compared to healthy subjects, but the change in peak VO2 after repeated CPET did not discriminate between patients and healthy controls.
Author information: Katarina Lien, MD, PhD research fellow at the Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway. Attending physician at the CFS/ME Centre, Department of Medicine, Oslo University Hospital, NorwayMailing address: Katarina Lien, Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 1046 Blindern, 0317 Oslo, Norway.E-mail address: katarina.lien@medisin.uio.noFunding: This project has been made possible by a research grant from the Norwegian
ExtraFoundation for Health and Rehabilitation. The grant proposal was submitted through the
CFS/ME patient organization MENiN – The ME Network in NorwayConflict of interest: None
aimossy
Senior Member
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Could that arterial collection be different from the other collections ie like the blood gasses artery?