Could this be IT ? - brain inflammation

[Martin aka paused||M.E.]

Theoharides has an own formulation, NeuroProtek, which you can buy to see if it helps with any symptoms. While it's an interesting hypothesis, I remember reading about this idea over five years ago. Curcumin and luteolin are easy to obtain and test for anyone, but I have yet to hear anyone getting cured or improving remarkably from taking them. It does seem obvious there is some brain inflammation going on in ME/CFS, but how to treat it is another matter, both curcumin and luteolin made me worse.

depends on what you expect... I’m a big fan of Youngers work and so came the idea to do a cortisone shock therapy with 1000 mg methylprednisolone (at my own risk - legal almost impossible in D). My doc wanted to start “carefully” and Gazve me The fırsat ınfusıon with 500mg. Then we had a day off to see how my body reacts. No side effects BUT after a few hours my brain fog was GONE next to my blurred vision and for the first time in many (7?) I didn't feel like having the flu (I tell ya it was great). Three infusions with 1g let the headaches disappear, the sensitivity and boys and girls I'm righting this text WITHOUT Ativan. Last week this would have been unthinkable (I'm very severe) I'm on

- Mizellen-Curcumin (don't know, in English perhaps Micell? My autocorrect purposes microphone-Curcumin but I guaranty you, I'm an expert in studio gear and it's NOT a mic!!!!)
- zystrosetea (still experimenting with the dose)
- LDN (3 mornings, 3 middays, so the 6 mg approach
- Rhodıola (makes me dizzy, but not too bad,
- St Johns wort.... tried every AD, the only one that worked is a mixture of two SSRI citalopram and megivenafucktralin... Kills your libido (bad, having a new GF) and even worse (your noodle stays where it has been when you really want)
- pro-/prebiotics bc I'm a tube user (read a book by Stanford researchers: when you can eat, eat things for your gut.... Don't buy pills)

That's a lot. But I want to erase the inflammation

Martin

 

[Stretched]

How about Tumeric - ‘seems I recall it was closely related to curcumin? I hope you’re feeling better in total. I remember you had a down spell a while back. Regrettably, my condition has deteriorated after a concussion, so I can appreciate your endurance efforts More in depth - it’s a real challenge! BION, there’s a post concussion syndrome (PCS, and/or traumatic brain injury, TBI) and it compounds MECFS and other neurological disorders. Actually exacerbates but that word has gotten irritating - ubiquitous, so overused, . Is there an ‘on the couch syndrome‘, OTC? (BION = believe it or not.)

 

[Wishful]

No side effects BUT after a few hours my brain fog was GONE next to my blurred vision and for the first time in many (7?) I didn't feel like having the flu (I tell ya it was great).

Please let us know if it continues, or fades after the treatment ends. Prednisone (normal dosage) gave me full remission the first two times I tried it, but the benefits faded after tapering off, and then never worked again.

 

[Rufous McKinney]

But I want to erase the inflammation

It feels very inflammatory here....and the desire to just Stop that Cycle somehow- sure seems desirable.

My husband had an odd ear thing- that ended up very inflammtory and it cleared after a bout of: corticosteroids. After a couple of weeks, it subsided and then cleared.

Keep us posted on your positive Progress!

 

[Wishful]

But I want to erase the inflammation

With all the possibilities for causing brain inflammation in ME, that might be difficult. Shutting down your inflammatory response could open you up to serious infections. Maybe you can find something that will reduce some of the response, but if the source of the inflammation remains, there's still a problem.

If the researchers can figure out which inflammatory pathways are involved, we might be able to use better targeted treatments. The cortisone shock therapy sounds like 'nuking the site from orbit'.

 

[Waverunner]

I agree with the part about oversensitive microglial cells, since that matches my observations. The mast cell part seems purely speculative at this point, so I'll wait until someone actually confirms it.

Luteolin didn't have a noticeable effect on me, and curcumin makes my symptoms much worse.

I don't know why this supplement contains Curcuma, but Curcuma can act as strong Th2 shifter, meaning it promotes rather than reduces the allergic immune pathways. There are several studies on Pubmed, especially for diseases like ulcerative colitis and Crohn's disease, where scientists show how it can induce the Th2 pathway (good for Crohn's, bad for UC).

 

[Martin aka paused||M.E.]

With all the possibilities for causing brain inflammation in ME, that might be difficult. Shutting down your inflammatory response could open you up to serious infections. Maybe you can find something that will reduce some of the response, but if the source of the inflammation remains, there's still a problem.

If the researchers can figure out which inflammatory pathways are involved, we might be able to use better targeted treatments. The cortisone shock therapy sounds like 'nuking the site from orbit'.

Jarred Younger himself wants to treat neuroinflammation with herbs and what can I say: I do it also and I went from very severe to severe in less than one week. I was very severe since 2 years%. Tried Copaxone, ..LDN and five million over things..... Now I'm on a bunch of anti-inflammatory herbs and yes. I don't think that now I get a victim of millions of viruses partying hard my brain.... Nope

 

[JES]

Jarred Younger himself wants to treat neuroinflammation with herbs and what can I say: I do it also and I went from very severe to severe in less than one week. I was very severe since 2 years%. Tried Copaxone, ..LDN and five million over things..... Now I'm on a bunch of anti-inflammatory herbs and yes. I don't think that now I get a victim of millions of viruses partying hard my brain.... Nope

Yeah but the problem is, Younger has found nothing really efficient to treat neuroinflammation with, else he wouldn't still be looking. Younger has also pointed out that we need to understand if neuroinflammation is just a brain igniting itself on fire or if neuroinflammation is a response to something, for example a pathogen. It doesn't also need to be a virus in the brain, research has shown that the brain can respond with inflammation e.g. coming from the gut.

The response you had to anti-inflammatories is fascinating. I don't want to put a curse on you, but I often noticed dramatic temporary improvements in brain fog from anti-inflammatory supplements including some herbal products, but they always stop working for me, sooner or later.

 

[Jo86]

Yeah but the problem is, Younger has found nothing really efficient to treat neuroinflammation with, else he wouldn't still be looking. Younger has also pointed out that we need to understand if neuroinflammation is just a brain igniting itself on fire or if neuroinflammation is a response to something, for example a pathogen. It doesn't also need to be a virus in the brain, research has shown that the brain can respond with inflammation e.g. coming from the gut.

The response you had to anti-inflammatories is fascinating. I don't want to put a curse on you, but I often noticed dramatic temporary improvements in brain fog from anti-inflammatory supplements including some herbal products, but they always stop working for me, sooner or later.

Interesting stuff.
About the very last sentence, could you give me a couple of examples ?

 

[Martin aka paused||M.E.]

Please let us know if it continues, or fades after the treatment ends. Prednisone (normal dosage) gave me full remission the first two times I tried it, but the benefits faded after tapering off, and then never worked again.

The treatment was three days, nearly two weeks ago....

 

[Martin aka paused||M.E.]

@JES Thanks for the typical PR-motIvating post btw: how do you now younger has already tested the herbs in a study?

 

[MonkeyMan]

There is a new drug being tested that has been shown to reduce brain inflammation. It's called IPW.

https://www.express.co.uk/life-styl...toms-support-reversed-drug-brain-inflammation

 

[Rufous McKinney]

There is a new drug being tested that has been shown to reduce brain inflammation. It's called IPW.

the term- Demented....is really offensive (used in the article above).

I'd like to propose this term be- term-inated.

This term was applied to both my parents. Neither were- demented.

Brain inflammation- good term.

 

[Wayne]

There is a new drug being tested that has been shown to reduce brain inflammation. It's called IPW.

From the article:

"Dementia has been reversed for the first time with a drug that reduces brain inflammation, say scientists. They hope that any drugs developed can also help after stroke, concussion or traumatic brain injury."​

​

DMSO is one of the best substances for reducing brain inflammation, and has (or was) used extensively in ER's for years to safely and quickly (within minutes) reduce brain inflammation from those suffering from a closed head injury. It was revolutionary at the time, and saved countless lives of people who would have otherwise died.

Assuming I had brain (and neck) inflammation, I began to apply DMSO topically to my neck area about three years ago. Within a short while, my Dysautonomia noticeably improved, and I had other improvements as well, including better brain cognition, and increased energy and stamina.

Regarding their hope the drug will also help stroke, concussion, and traumatic brain injury: My understanding is the best therapy available right now--with virtually no risks--is Hyperbaric Oxygen Therapy (HBOT). Since getting my home unit about 1.5 years ago, I feel my brain has healed considerably from the ravages of Lyme, CFS, concussions, and chronic brain inflammation.

I feel my brain right right now is functioning far better than it was 26 years ago when I was forced to quit working. I credit DMSO and HBOT for most of that improvement, but getting into the habit of going 16-18 hrs a day without food (intermittent fasting) has also improved my digestion and brain function. I'd say my brain function is now up to, oh. about 40% or so. So I continue to strive for improvements. -- Huperzine A has been really good.

 

[MonkeyMan]

DMSO is one of the best substances for reducing brain inflammation, and has (or was) used extensively in ER's for years to safely and quickly (within minutes) reduce brain inflammation from those suffering from a closed head injury. It was revolutionary at the time, and saved countless lives of people who would have otherwise died.

Assuming I had brain (and neck) inflammation, I began to apply DMSO topically to my neck area about three years ago. Within a short while, my Dysautonomia noticeably improved, and I had other improvements as well, including better brain cognition, and increased energy and stamina.

VERY interesting. I see it's available on Amazon. I'm going to order some. Any side effects that you've noticed?

 

[Hip]

There is a new drug being tested that has been shown to reduce brain inflammation. It's called IPW.

https://www.express.co.uk/life-styl...toms-support-reversed-drug-brain-inflammation

More detailed article on this drug IPW-5371 here.

DMSO is one of the best substances for reducing brain inflammation

Would you have a reference for that: I can't find anything on anti-neuroinflammation effects of DMSO via a quick Google search.

 

[MonkeyMan]

More detailed article on this drug IPW-5371 here.

Thanks Hip. @Janet Dafoe (Rose49) @Ben H - Are Ron Davis and/or Jarred Younger aware of this drug and/or have tested it?

 

[Rufous McKinney]

Would you have a reference for that: I can't find anything on anti-neuroinflammation effects of DMSO via a quick Google search.

Here is a reference...to lowering cytokines...further study needed.

https://www.ncbi.nlm.nih.gov/pubmed/27031833


PLoS One. 2016 Mar 31;11(3):e0152538. doi: 10.1371/journal.pone.0152538. eCollection 2016.
DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis.
Elisia I1, Nakamura H1, Lam V1, Hofs E1, Cederberg R1, Cait J2, Hughes MR2, Lee L1, Jia W3, Adomat HH4, Guns ES4, McNagny KM2, Samudio I1, Krystal G1.

"Topical administration of DMSO, however, significantly mitigated K/BxN serum-induced arthritis in mice, and this was associated with reduced levels of pro-inflammatory cytokines in the joints and white blood cell levels in the blood. Thus, while we cannot confirm the efficacy of DMSO as an anti-cancer agent, the use of DMSO in arthritis warrants further investigation to ascertain its therapeutic potential."

 

[Hip]

Here is a reference...to lowering cytokines...further study needed.

I know DMSO is used as an anti-inflammatory in animals, such as race horses. However, that does not mean it can necessarily reduce brain inflammation.

 

[Wayne]

Would you have a reference for that: I can't find anything on anti-neuroinflammation effects of DMSO via a quick Google search.

@Hip -- I just went through some of my many DMSO bookmarks, and unfortunately, probably more than half are no longer working. I did find the following however:

Dimethyl Sulfoxide Lowers ICP After Closed Head Trauma

DMSO Background Literature

The following article has a lot of references:

DMSO: The Real Miracle Solution

The rest of these articles should give you better clues on what DMSO is purported to do, and how well its backed up by scientific literature:

The Untapped Healing Potential of DMSO

DMSO and MSM

Insulin Potentiation Therapy (IPT)

The natural cure for cataracts

(I put small amounts of DMSO on my eyelids regularly, and it has really helped my eye health)​

I wrote fairly extensively on my own DMSO experimentation at the following link:

POTS Inexplicably Improves After Topical DMSO Applications
.....................................

I sent the following email to some friends several years ago:

I run across an old 1964 LIFE magazine article on DMSO, and came across a couple of really interesting sections.

1) ... A doctor friend of his twisted an ankle one day, and Jacob promptly daubed it with DMSO. Later, looking at X-rays of the lower leg, both Jacob and his friend were horrified to learn that DMSO had killed the pain so effectively that the man had been walking around for four hours with a broken shinbone.

2) [Back in 1964] ... started looking for new uses for DMSO as a solvent. "We tried it first on notoriously hard-to-dissolve substances like pesticides," he recalls. "DMSO dissolved them easily. We then checked to see how pesticides in DMSO worked on trees. We found they began to move around with amazing speed--not just in the conducting systems under the bark, but right through nonliving layers of wood. The pesticides were colored so we could see them spreading out."

Agricultural experts helped adapt this discovery into a method which may do away with conventional spraying of trees. Pesticides in DMSO are piped into trees the way intravenous drips are put into the arms of patients. They spread to protect leaves and fruit from an impressive roster of mildews, blights, scabs and cankers. DMSO has other agricultural possibilities and even seems to rejuvenate fruit trees that have become barren.

Here's a final note about DMSO and heavy metals from a separate article. Interestingly, the health website--Advanced Rejuvenation Institute--where I got the below snippet offers IV DMSO at their clinic in Atlanta, Georgia.

Are There Other Benefits to DMSO?

Yes. DMSO can assist in Heavy Metal Detoxification. Heavy metals ( mercury, lead, aluminum, cadmium, arsenic, nickel ) are very difficult to detoxify from, and they are the root of many diseases. Sulfur is a mineral and a major ingredient of certain amino acids, which bind with minerals or heavy metals. Body drops heavy metals for minerals, which in this case would be sulfur. Amino acids substitute sulfur for toxic heavy metals, bind with them, and eliminate them via urination, defecation and sweating. Also, DMSO is efficient at scavenging free radicals. It is perfect anti-oxidant.