This is such a interesting conversation.
I have to low ceruloplasmin.
Between 20-60 is normal and my ceruloplasmin is 18.
I did years very wel on zinc, and b6 but now anymore.
My histamin intolerance is getting worse and worse because low intracellulair copper. My bio unavailible copper is to high! ( they did test me in hospital, to low copper, to low ceruloplasmin but to high unbound copper).
But just like with patients with Wilson disease you cant take more copper thats dangerouse.
Because copper gets higher you get lower zinc levels.
Zinc is a co factor for methylation with vitamin b6.
You need zinc to absorb b6. (Make p5p from zinc).
But with to low copper , ceruloplasmin is getting lower and worse.
With low copper and so high histamin you get more and more (food) allergies.
With more histamin /mast cells you get zinc depletion..
Because zinc is a mast cell stabiliser.
Zinc is getting depleted , so no co factor for methylation, is lower glutathion production. But also because of high histamin, more allergies are produced.
And most people with auto-immuun are all low in zinc and have often much Allergies... Now we do understand why moet of us do good on paleo aip and low histamin diet. And why most people with auto-immuun conditions always have depleted zinc levels also with high enough intake. (For example diabetes).
So what now?
I was following a low copper diet and did take high zinc.(just like wilson patients). That was working because it did reduce my copper.( But also my good intracelulair copper even more. )
My neurological symptoms(parkinson like) did went away.
Only it is making my histamin intolerance much worse because low DAO enzym from the liw copper. So now more food allergies and more histamin production. So more depletion of zinc have to take more and more from it.
Taking more copper isnt the answer and dangerouse just like with wilson patients with liw ceruloplasmin. Maybe i have to try a low histamin diet(aip).im looking for een answer into that. If someone had got a clue be my guesst.
(Sorry for the bad englisch, im from the netherlands).