yeah copper is needed for methylation but i forgot in which step exactlyDoes anyone know how copper is related to methylation and/or SAMe? I have read somewhere that it raises homo cysteine levels but it does not seem to be a good study. Could Cu be supporting some enzyme production involved in methylation?
It seems that copper supplementation doesn't give you any benefits.I also have copper dysregulation. Although when I start taking copper even 2mg a day my peripheral neuropathy in the right leg and right knee and hip joint pain significantly increases. I also become more irritable. Should I push through it?
But I show signs of copper deficiency all my life and my serum is low. I have ridges on my fingernails and that maybe lack of copper as well.It seems that copper supplementation doesn't give you any benefits.
I think my ridges are worse than yours and I can't tolerate copper supplements at all, unless occasionally in the recommnended proportion to zinc and selenium.But I show signs of copper deficiency all my life and my serum is low. I have ridges on my fingernails and that maybe lack of copper as well.
I think my ridges are worse than yours and I can't tolerate copper supplements at all, unless occasionally in the recommnended proportion to zinc and selenium.
BTW I never read that nail ridges are caused by low copper, rather by low zinc instead.
I also have copper dysregulation. Although when I start taking copper even 2mg a day my peripheral neuropathy in the right leg and right knee and hip joint pain significantly increases. I also become more irritable. Should I push through it?
How long have you been taking copper ? If the neuropathy and joint pain are due to copper deficiency, it may take months to improve.
Also, pain can temporarily worsen before it gets better. With copper deficiency, iron accumulates in organs and joints, along with calcium.
Anything that mobilizes iron, which copper does, along with retinol, choline, B6, other B's, etc. will cause some discomfort, pain, inflammation for a time.
I've read that copper can lower gaba production. That could also make somebody irritable, along with excess iron moving around.
It's unfortunate that we're made to fear copper....
MeB12 helped my neuropathy and sciatica.
Copper enzymes will help teeth and bones, but that takes a lot of time.
I've been having a lot of trouble with teeth and bones. I'm back to taking lactoferrin for that, along with copper. Lactoferrin is protective of Ceruloplasmin, a copper protein. It can also chelate copper, so it's good to have both.
Lowering inflammation has helped my sleep. Infections were the main cause. Copper, Retinol, and Lactoferrin have been the most effective, for me at least.
At first when I started with MeB12 and methylfolate my sciatica and neuropathy were gone but it came back with other B12 deficiency symptoms.
I will try to titrate copper slowly and see how that goes. I'm glad you could lower your inflammation and make copper work for you. How much copper a day you take?
sorry for jumping years later into this. but i find this copper histidine connection interesting because that i can supplement where as coeruluplasmin i cant.I think you are putting a misleading slant on the role of histidine, implying that the amino acid per se is doing all these things.
It is certainly true that histidine plays an important role in maintaining the co-ordinate bonds which attach metals to metalloproteins, but it performs these functions as part of the three dimensional structure of the protein.
Histidine supplementation (whether direct or indirect through carnosine) might be helpful if there is dietary deficiency but it will exert these beneficial effects once it is incorporated into protein.
Do you have any evidence for this statement?
I did read the reference you linked and a reference linked in the link, but these are simply characterising the nature of the copper-histidine bond in vitro, nothing to do with the amino acid acting in vivo as a copper shuttle.
Copper and histidine have a significant connection in biological systems. Histidine is an amino acid that contains an imidazole group, which can bind to metal ions like copper. Copper, on the other hand, is an essential trace element that plays a vital role in various biological processes.
In proteins, histidine residues often serve as ligands for copper ions, coordinating with the copper atom through the imidazole nitrogen atoms. This coordination helps stabilize the copper ion within the protein structure and allows it to participate in specific enzymatic reactions.
One well-known example is the copper-binding protein ceruloplasmin, which contains multiple histidine residues that coordinate with copper. Ceruloplasmin is involved in transporting and oxidizing iron, as well as protecting against oxidative damage. The copper ions bound to histidine residues in ceruloplasmin facilitate its enzymatic activity.
In addition to ceruloplasmin, copper-dependent enzymes such as copper/zinc superoxide dismutase (SOD1) and dopamine β-monooxygenase also utilize histidine residues to coordinate copper ions and carry out their respective functions.
Overall, the interaction between copper and histidine is crucial for the proper functioning of various copper-containing proteins and enzymes in biological systems.