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So as some of you might know, I took Ciprofloxacin in December 2015 and after eight days my ME started to worsen.
I was still mild, but suffered from brutal pain and my POTS started. I had ant running in all extremes and sometimes paralysis, heart rate problems, blurred vision and EXTREME muscle pain (11/10) and was very fatigued. It got better until summer and then after one week of diarrhea it all came back.
Due to a floxed friend who has still reservoirs of Ciprofloxacin after almost ten years in her cells I decided to do a test.
Mind you, the results are concerning.
Ciprofloxacin enters cells and destroys mtDNA. Now I ask myself of this could also be a driving factor not only for my worsening but also for me severity that keeps me in bed.
Your thoughts are welcome and appreciated!
https://pubmed.ncbi.nlm.nih.gov/30169847/
I was still mild, but suffered from brutal pain and my POTS started. I had ant running in all extremes and sometimes paralysis, heart rate problems, blurred vision and EXTREME muscle pain (11/10) and was very fatigued. It got better until summer and then after one week of diarrhea it all came back.
Due to a floxed friend who has still reservoirs of Ciprofloxacin after almost ten years in her cells I decided to do a test.
Mind you, the results are concerning.
Ciprofloxacin enters cells and destroys mtDNA. Now I ask myself of this could also be a driving factor not only for my worsening but also for me severity that keeps me in bed.
Your thoughts are welcome and appreciated!
https://pubmed.ncbi.nlm.nih.gov/30169847/
We report here that both known type II topoisomerases Top2α and Top2β are present in mammalian mitochondria, with especially Top2β regulating the supercoiling state of mtDNA. Loss of Top2β or its inhibition by ciprofloxacin results in accumulation of positively supercoiled mtDNA, followed by cessation of mitochondrial transcription and replication initiation, causing depletion of mtDNA copy number. These mitochondrial effects block both cell proliferation and differentiation, possibly explaining some of the side effects associated with fluoroquinolone antibiotics. Our results show for the first time the importance of topology for maintenance of mtDNA homeostasis and provide novel insight into the mitochondrial effects of fluoroquinolones.