Xara
Senior Member
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I think the donut hole was that there was enough methylfolate to start the healing (thus the need for potassium) but not enough for maintaining it. Ergo: one has to give lots of methylfolate (then the hole closes).So let me see if I got this straight.
If someone were to say take only 400-800 mcg of methylfolate (and maybe to make things worse at the same time eat a couple hundred micrograms of vegetable folate a day) but take a dose of say 5000-10000 mcg of 5 star sublingual mb12 they will in fact probably burn through their methylfolate rapidly and end up with a donut hole methyfolate insufficiency but also get hit with the high need for potassium?
On the other hand if they take high doses of methylfolate and say get only a 100 mcg of mb12 absorbed they run a high risk of a methyl trap?
So if someone is kind of near a balance point between the too, but wants to increase they are better off raising both mb12 and methylfolate together (provided there is enough ATP via LCF and adb12 to go along for the ride)?
But one can not give lots of methylfolate when there's not enough mB12, because then the methylfolate will flush out of the cells, giving methylfolate deficiency symptoms. One needs to increase the mB12.
When you do not give enough mB12, you'll see b12 deficiency symptoms. As soon as all the mB12 is used up you get again methylfolate to flush out of the cells and you'll see the methylfolate deficiency symptoms again.
So I'd say yes, you have to (try to) balance them and raise them both if you don't want to get trapped in a donut
Well, at least that's how I perceived it.