I've been taking csm for almost three years now, and at significant dosages (though rarely at four packages per day) for almost two years.
At least for me, I don't think that Shoemaker is correct in suggesting that people take four doses, evenly spaced, during the daytime hours.
My own body seems to do most of its detoxifying at night. This seems to be the case for other people too (which could be why ME/CFS patients almost all feel like crap when they wake up).
Thus, taking csm in the middle of the day isn't that sensible.
At first, I did try the evenly spaced method. But as time went on, I started shifting more and more to taking it in the evening hours, plus a dose in the morning.
This usually turns out to be a dose an hour or two before bed, a dose before bed, and a dose in the morning. Sometimes I will wake up in the middle of the night and feel like having a dose. Occasionally I will feel like it's a good idea to do a dose in the middle of the day, but not too often.
Mostly I'm just doing this by intuition. I take it when it feels like a good idea, or when I feel sensations of heartburn (I think this is actually the presence of chemicals), or when I think of it. If I'm detoxifying fast for some reason (because I've recently had a big hit, because I'm in the Godforsaken wilderness, because I'm promoting detox heavily with methylation etc.), I'll take more. If it doesn't seem like I'm benefiting much, I take less.
YMMV.
Best, Lisa