Bhupesh Prusty: "we are on a perfect path for identifying potential transferable factors in ME/CFS blood that can cause mito dysfunction..." GoFundMe

Gemini

Gemini

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Murph said:
Prusty is the guy who added me/cfs serum to cells and was able to watch the mitochondria react by splitting up into small pieces (mitochondrial fission).
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@Murph, thanks for posting this promising update!

Wonder if one of the potential diagnostic tests Prusty eludes to here is Ron Davis' nanoneddle that's referenced by Naviaux with whom he's collaborating? See link:

https://forums.phoenixrising.me/threads/naviaux-lab-newsletter-me-cfs-research-plan-for-2020.78743/
 
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Gemini

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kafkalee said:
So, he thinks it is HHV6?

If it was transfer factor problem, what can we do to fix it?

is 'potential transferable factor' means transfer factor?
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@kafkalee Prusty {1:39 on video} thinks many types of viruses i.e., herpses and others, may have similar strategies that might cause the same kind of mito fragmentation that HHV-6A does.

Interestingly when he removed ME/CFS blood from the cells, mito function reverted to normal.

He was trying to identify the factor in the ME/CFS blood causing mito dysfunction which he thought might be extracellular, small RNA, ROS or perhaps protein at the time of the video. Excitingly he may have identified a factor according to this tweet.

Not sure what he means by "transferable factor " here. By transfer factor, do you mean the one studied as a possible ME/CFS treatment many years ago?

It's nice to see he's working with Dharam Ablashi, HHV-6 expert and ME/CFS advocate over many years.
 
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R

RL_sparky

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Dr. Prusty mentioned recently that he has a major paper on ME due out early this year. He is very tight on funds and even uses part of his own money to keep things moving.
He told me the best way to donate is to do it through the HHV6 Foundation and then email them to direct the funds to him.
Here is a link: https://hhv-6foundation.org/about-us/donate

He is making progress and could use some financial support.
 
xebex

xebex

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Yes I agree with Ruphus. By transferable it means he can transfer the effect into healthy serum.

My thoughts are that the virus (or one of several viruses) change the way the brain behaves, (then buggers off so isn't detectable) maybe it even makes the brain secrete a hormone (the thing being found in the blood) that’s hasn’t been discovered yet that makes us “hibernate”. Just speculation.

My question is if 95% of people have hhv6 something else (maybe genetics) allows the virus to behave this way when in most people it has no effect. Possibly the virus lies dormant until a stressor ie another virus or an accident or severe stress come along and kick start it.
 
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Rufous McKinney

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xebex said:
By transferable it means he can transfer the effect into healthy serum.
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I always knew I should never donate blood and I never have (Prusty advises against)..

That my blood is NOT ok, and I would not wish it upon anyone else..is a truth here.

We all have our theories- as we experience our own bodies...

We hibernate because of the sickness response...its the appropriate response. The message- Your Really Sick..is a real message. Its not an invention.

Once I have saturated myself in anti-inflammatory herbs...this body starts to work ok, it seems to find energy, it seems to issue more correct instructions...it is not so faint, so weak. Actual energy is getting out to the parts its not reaching earlier in the day. It seems like- the lower brain stem is less inflammed and can now send out more correct instructions for the body to work. I have alot of physical swelling of tissues and why shouldn't my lower brain- right next to all those tissues- not also be affected? Its all swelling up around there.

So I have...tended to view all this as- related to the virus, long term weakening the collagen, allowing the brainstem to collapse, further inflamming, cycle repeat rinse repeat. And if you can get that inflammed swelling to go down, more proper instructions..and maybe more properly operating mitos...take over..for a while.
 
godlovesatrier

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Surely there must be a genetic factor of pre-disposition? Take army soliders. They get vacinnated for all sorts, but they also don't get sick often due to a much stronger immune response. These men and women would be highly susceptible to a disease like ME after getting sick because of the physical stresses and demands placed on them daily. But they are all fine, apart from I would assume a tiny number who are not.

So there must be a genetic factor of pre-disposition, possibly even a gene that is turned on to create the ability for something (whatever it is) to disrupt mitochondrial function.
 
Rufous McKinney

Rufous McKinney

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godlovesatrier said:
Surely there must be a genetic factor of pre-disposition? Take army soliders. They get vacinnated for all sorts, but they also don't get sick often due to a much stronger immune response. These men and women would be highly susceptible to a disease like ME after getting sick because of the physical stresses and demands placed on them daily. But they are all fine, apart from I would assume a tiny number who are not.
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Gulf War Syndrome affected about 1/3 of the troops sent over to the Persian Gulf, per Wikipedia. (250,000/690,000)

So we suspect a genetic predisposition for ME...and about 2% of the population has ME.

With GWS, thats clearly a much larger percentage. So if a genetic predisposition was required- well alot of people succumbed.

These poor people.
 
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