I have only a generel input, don´t know if it can hold any water:
In the brain there are a lot of metals. The most natural guess is, that they will have tasks. For some prominent metals some tasks are known, for zinc e.g.
So, if one wants to change the actions in the brain, it might be helpful to replace the metals.
This can be done by chelating them (a known and easy to get chelator is citrate acid) and to take them in at a different time (chocolate contains metals).
Additionally a change of epigentics porobably would be desireable. VitB12 is known for a methylation, but there are other -ations, one should be acetylation (wikipedia
What I am doing now on my example of mecfs is: putting juice from a lemon in 1l water, adding 2 drops of b12, [half a drop of vinegar for] acetate (well, it has an effect, dont know if it´s the supposed one -), and drinking from it (taking a straw) over some time, hours, a day, it depends. Later I am happy to eat some chocolate, though not too much, up to 37g.
As I said, I don´t know how much of an effect it could have on withdrawl, but for my changes it´s marvellous.