outdamnspot
Senior Member
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- 924
I know methylation has been covered so much here, but I just don't have the mental capacity to go through it all, so wanted to ask a couple of questions, if that's okay.
I started using Greg's B12 oil 2.5 weeks ago (the methyl/adenosyl mix); at first, the effects were really strong (euphoria, increased mental energy, better sleep, mixed effects on physical energy .. sometimes triggering crashes etc.). Then things started to taper off and I'd mostly just notice a little relaxation and what I think is electrolyte imbalances immediately after applying it (worsened POTS, anxiety, weakness in my limbs.). I do take quite a lot of potassium though, since I'm on a Keto diet.
Anyway, I began consuming beef liver once a week, but switched to eating it everyday last week, because it was the only carbohydrate source I could tolerate. I noticed that the combination of the B12 and beef liver seemed to have a very powerful immune effect: my gut became a complete mess and I was spending nearly all day 'clearing out' the strangest stuff (normally I have almost no gut motility). The B12 alone didn't do that and the liver alone didn't do that, so I thought maybe the folate and vitamins in the liver were helping move methylation along? It felt different to my regular food reactions because if I eat something that irritates my gut, I just get diarrhea, but this felt closer to the die-off I've experienced on herbal abx; I would feel amazing relief after each 'elimination'.
However, the liver definitely causes a histamine reaction in me too and suddenly yesterday I became intolerant to it so had to stop. I also noticed that my hands are covered in a rash and that I have a lot of painful cracks that look like small papercuts. I was wondering:
a) could the cuts on the hands and dry skin be paradoxical folate deficiency from the folate in the liver? I don't have anything like angular chelitis etc. so was wondering if I was doing more harm or good by eating the liver.
b) if I wanted to continue on the B12, is it necessary to introduce methylfolate too? I have the double MTHFR mutation. And if I do, can I take a small dose before bed or does it tend to be stimulating? I do prefer to take new supplements before bed in case they trigger a crash.
c) if I introduced methylfolate, would I have to cut out folate-containing foods like liver, avocados etc.?
Any insights would be appreciate. Thanks!
I started using Greg's B12 oil 2.5 weeks ago (the methyl/adenosyl mix); at first, the effects were really strong (euphoria, increased mental energy, better sleep, mixed effects on physical energy .. sometimes triggering crashes etc.). Then things started to taper off and I'd mostly just notice a little relaxation and what I think is electrolyte imbalances immediately after applying it (worsened POTS, anxiety, weakness in my limbs.). I do take quite a lot of potassium though, since I'm on a Keto diet.
Anyway, I began consuming beef liver once a week, but switched to eating it everyday last week, because it was the only carbohydrate source I could tolerate. I noticed that the combination of the B12 and beef liver seemed to have a very powerful immune effect: my gut became a complete mess and I was spending nearly all day 'clearing out' the strangest stuff (normally I have almost no gut motility). The B12 alone didn't do that and the liver alone didn't do that, so I thought maybe the folate and vitamins in the liver were helping move methylation along? It felt different to my regular food reactions because if I eat something that irritates my gut, I just get diarrhea, but this felt closer to the die-off I've experienced on herbal abx; I would feel amazing relief after each 'elimination'.
However, the liver definitely causes a histamine reaction in me too and suddenly yesterday I became intolerant to it so had to stop. I also noticed that my hands are covered in a rash and that I have a lot of painful cracks that look like small papercuts. I was wondering:
a) could the cuts on the hands and dry skin be paradoxical folate deficiency from the folate in the liver? I don't have anything like angular chelitis etc. so was wondering if I was doing more harm or good by eating the liver.
b) if I wanted to continue on the B12, is it necessary to introduce methylfolate too? I have the double MTHFR mutation. And if I do, can I take a small dose before bed or does it tend to be stimulating? I do prefer to take new supplements before bed in case they trigger a crash.
c) if I introduced methylfolate, would I have to cut out folate-containing foods like liver, avocados etc.?
Any insights would be appreciate. Thanks!