datadragon
Senior Member
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Hi Mary yes you have had some non typical reactions such as insomnia or perhaps glutamate or glutamate/gaba balance being an additional issue to deal with for you beyond say just the core effect of nlrp3 inhibition lowering ifn-y and ability to lower wasf3 levels that should help many to focus on especially where something like a virus or fructose also in table sugar or heavy exercise is likely fueling nlrp3 activation in the earlier stages.RBC tests always show my magnesium level is okay. I've been taking magnesium glycinate for years and years. I also take B6 daily, in the morning. If I take it at night, it gives me insomnia. And I take NAC daily, in the morning. Several years ago someone on PR posted that it helped with sleep because of its effect on glutamate, so I started taking it at night. At first it helped, and then it switched, causing insomnia. It took awhile to figure this one out but I finally did, with help from reddit.
You can see if switching to magnesium sulfate works better then the glycinate in this case.
On b6 just remember to avoid pyridoxine which inhibits the active p5p form and stick to p5p but trying to take more of a rda dose not a large dose as during inflammation any zinc or mag deficiency can make it not go in the cell and become more inflammatory not anti inflammatory. However most recently it appears that zinc and magnesium are cofactors that also are needed for B6 entry into the cell I found as well, so zinc and magnesium deficiency/unavailability may further impair utilization of vitamin B6 during inflammation/infection states even when supplementing such as using the active form P5P. This may be why B6 levels become high instead during that time fueling serine and inflammation or immune response https://forums.phoenixrising.me/thr...duction-utilization.57030/page-3#post-2440317
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