BCAAs reducing PEM

[datadragon]

RBC tests always show my magnesium level is okay. I've been taking magnesium glycinate for years and years. I also take B6 daily, in the morning. If I take it at night, it gives me insomnia. And I take NAC daily, in the morning. Several years ago someone on PR posted that it helped with sleep because of its effect on glutamate, so I started taking it at night. At first it helped, and then it switched, causing insomnia. It took awhile to figure this one out but I finally did, with help from reddit.

Hi Mary yes you have had some non typical reactions such as insomnia or perhaps glutamate or glutamate/gaba balance being an additional issue to deal with for you beyond say just the core effect of nlrp3 inhibition lowering ifn-y and ability to lower wasf3 levels that should help many to focus on especially where something like a virus or fructose also in table sugar or heavy exercise is likely fueling nlrp3 activation in the earlier stages.

You can see if switching to magnesium sulfate works better then the glycinate in this case.

On b6 just remember to avoid pyridoxine which inhibits the active p5p form and stick to p5p but trying to take more of a rda dose not a large dose as during inflammation any zinc or mag deficiency can make it not go in the cell and become more inflammatory not anti inflammatory. However most recently it appears that zinc and magnesium are cofactors that also are needed for B6 entry into the cell I found as well, so zinc and magnesium deficiency/unavailability may further impair utilization of vitamin B6 during inflammation/infection states even when supplementing such as using the active form P5P. This may be why B6 levels become high instead during that time fueling serine and inflammation or immune response https://forums.phoenixrising.me/thr...duction-utilization.57030/page-3#post-2440317

 

[Mary]

@datadragon - I also take zinc and have for many years. I think you know that insomnia is a huge issue for most of us on this form. It goes hand-in-hand with MECFS.

 

[datadragon]

I also take zinc and have for many years. I think you know that insomnia is a huge issue for most of us on this form. It goes hand-in-hand with MECFS.

Let me make this much easier for you and others to understand. As far as Glycine's acute effects on glutamate, it can be directly used as a NMDA receptor ligand, on the glycine binding site. That means in some ways it is a glutamate supplement, allowing NMDA receptors to work in the first place. The N-methyl-D-aspartate receptor, is a glutamate receptor. So perhaps the form like a magnesium glycinate or solgar zinc glycinate (solgar chelated zinc) might not work well for this situation, why I suggested to try magnesium sulfate instead for example. Glutamine also can increase glutamate why I mentioned some other nlrp3 inhibitors

The mechanism by which wasf3 levels are causing the pem https://www.healthrising.org/blog/2023/08/16/nih-mitochondria-chronic-fatigue-syndrome/
can be helped for many with those nlrp3 inhibitors or ifn-y inhibitors, but then it’s not just er stress but infection inflammation glucose fructose heavy exercise etc all happen to converge to increase wasf3 levels via nlrp3 activation or increase in ifn-y. The additional issue has been that several nutrients go deficient during an infection/inflammation state or that nlrp3 activation such as zinc for example gets placed into the cell and its absorption is lowered both so it’s not easily restored without using a chelated form. . From there this can cause problem with vitamin b6 and other nutrients in a further cascade where it’s needed with b6 for example to convert it to the active form and get it into the cell, otherwise b6 would be more inflammatory rather than it’s usual anti inflammatory effects. So yes we may need an extra step like a chelated zinc that is not glycinate although I was hoping the lowering of inflammation would restore the zinc metabolism and lessen its additional requirement in some people.