Would I need to take B2 always with B12 or just take B2 to boost levels, then take B12 again without B2?
One of the most important lessons I have learned is that everyone is biochemically different which means what works for one person may not work for another.
You would almost have to isolate each b vitamin and test and observe then adjust. Based on some general ideas, I would choose B2 since it is supportive of immune function and also adrenal function. B6 would be my next choice then B5 (pantothenic acid). If you are experiencing adrenal issues (POTS) then these are critical vitamins since they support adrenal activity. But there are other nutrients that support adrenal activity such as Vitamin C and magnesium etc.
Choline works very well for me. It works better when I use choline/inositol, not just choline.
>>>>>>these below would be on my bottom choices >>>>>>>>>>>
B12 generally ramps up metabolism which might be ok if you have other supporting b vitamins. Folic acid is in the same family as B12 which MAY do the same as B12.
B3 (niacin or niacinamide) has a tendency to accelerate metabolism which causes panic attack feelings.
B1 is generally considered to be energy stimulating but some on this forum have reported benefits from taking it.
PABA is a no no for me.
Biotin is neutral for me.
If you do the experiment, don't forget to post your findings. This helps us and the future people who will visit the forum looking for help.