association between low MBL2 genotypes and pediatric OCD, particularly PANDAS-OCD

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Published online 2018 Oct 25. doi: 10.29399/npa.22811

Mannose-Binding Lectin 2 Gene Polymorphism in PANDAS Patients

Gonca Gül Çelik,1 Didem Arslan Taş,2 Ayşegül Yolga Tahiroglu,1 Eren Erken,2 Gülşah Seydaoğlu,3 Perihan Çam Ray,1 and Ayşe Avci1

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Abstract

Introduction:
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), a subgroup of obsessive-compulsive disorder (OCD), has received much attention even though the specific underlying mechanisms remain unknown. Mannose-binding lectin (MBL) is a key factor in the innate immune response.

The aim of this study was to investigate the role of MBL2 gene polymorphisms in pediatric OCD patients diagnosed as PANDAS, PANDAS-Variant and non-PANDAS.

Methods:

The study included 102 pediatric OCD patients (59 [57.8% ] PANDAS, 20 [19.6% ] non-PANDAS, and 23 [22.5% ] PANDAS-Variant) and 60 healthy controls. Polymorphisms at codon 52, 54 and 57 of the MBL2 gene were investigated.

Results:

Codon 54 polymorphism and any variant of MBL2 gene were significantly more frequent in the OCD group than in the control group (OR=2.97, 95% CI: 1.26–6.97; and OR=2.66, 95% CI: 1.32–5.38, respectively).

According to regression analysis, the presence of any variant of MBL2 gene was found in 14.50-fold increased frequency in the PANDAS subgroup compared with the non-PANDAS subgroup (95% CI: 2.49–84.19).

Conclusions:

Our findings support an association between MBL2 genotypes and pediatric OCD, particularly PANDAS-OCD.

Keywords:

Mannose-binding-lectin2 gene, obsessive-compulsive disorder, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections