association between low MBL2 genotypes and pediatric OCD, particularly PANDAS-OCD

pattismith

Senior Member
Messages
3,423
Likes
6,688
Published online 2018 Oct 25. doi: 10.29399/npa.22811

Mannose-Binding Lectin 2 Gene Polymorphism in PANDAS Patients

Gonca Gül Çelik,1 Didem Arslan Taş,2 Ayşegül Yolga Tahiroglu,1 Eren Erken,2 Gülşah Seydaoğlu,3 Perihan Çam Ray,1 and Ayşe Avci1

Author information Article notes Copyright and License information Disclaimer
This article has been cited by other articles in PMC.

Introduction:
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), a subgroup of obsessive-compulsive disorder (OCD), has received much attention even though the specific underlying mechanisms remain unknown. Mannose-binding lectin (MBL) is a key factor in the innate immune response.

The aim of this study was to investigate the role of MBL2 gene polymorphisms in pediatric OCD patients diagnosed as PANDAS, PANDAS-Variant and non-PANDAS.
The study included 102 pediatric OCD patients (59 [57.8% ] PANDAS, 20 [19.6% ] non-PANDAS, and 23 [22.5% ] PANDAS-Variant) and 60 healthy controls. Polymorphisms at codon 52, 54 and 57 of the MBL2 gene were investigated.
Codon 54 polymorphism and any variant of MBL2 gene were significantly more frequent in the OCD group than in the control group (OR=2.97, 95% CI: 1.26–6.97; and OR=2.66, 95% CI: 1.32–5.38, respectively).

According to regression analysis, the presence of any variant of MBL2 gene was found in 14.50-fold increased frequency in the PANDAS subgroup compared with the non-PANDAS subgroup (95% CI: 2.49–84.19).
Conclusions:
Our findings support an association between MBL2 genotypes and pediatric OCD, particularly PANDAS-OCD.
Keywords:
Mannose-binding-lectin2 gene, obsessive-compulsive disorder, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections